Metformin induces apoptosis via uterus mitochondrial permeability transition pore opening and protects against estradiol benzoate-induced uterine defect and associated pathophysiological disorder in female Wistar rats

Metformin induces apoptosis via uterus mitochondrial permeability transition pore opening and protects against estradiol benzoate-induced uterine defect and associated pathophysiological disorder in female Wistar rats

Abstract Background Some antitumor or anticancer agents have been shown to execute cell death by induction of mitochondrial permeability transition (mPT) pore opening in order to elicit their chemotherapeutic effect. Therefore, this study investigated the effect of metformin on cell death via rat ut...

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Bibliographic Details
Main Authors: Adeola Oluwakemi Olowofolahan, Obinna Matthew Paulinus, Heritage Mojisola Dare, Olufunso Olabode Olorunsogo
Format: Article
Language:English
Published: SpringerOpen 2021-06-01
Series:Bulletin of the National Research Centre
Subjects:
Apoptosis
Cancer
Metformin
Mitochondria
Mitochondrial permeability transition pore
Online Access:https://doi.org/10.1186/s42269-021-00562-6

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