The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy
<p><strong>Aim:</strong> The study aimed to determine the predictive value of retrograde pressure (RP) indicators and cerebral oxygenation in the evaluation of ischemic brain damage during carotid endarterectomy (CEA).<br /><strong>Methods:</strong> This nonrandom...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2016-08-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/350 |
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| author | А. А. Карпенко Р. А. Кужугет О. В. Каменская П. В. Игнатенко В. Б. Стародубцев А. Н. Шилова |
| author_facet | А. А. Карпенко Р. А. Кужугет О. В. Каменская П. В. Игнатенко В. Б. Стародубцев А. Н. Шилова |
| author_sort | А. А. Карпенко |
| collection | DOAJ |
| description | <p><strong>Aim:</strong> The study aimed to determine the predictive value of retrograde pressure (RP) indicators and cerebral oxygenation in the evaluation of ischemic brain damage during carotid endarterectomy (CEA).<br /><strong>Methods:</strong> This nonrandomized, prospective pilot study included 87 patients with asymptomatic stenosis greater than 70% who underwent carotid endarterectomy under general anesthesia. Brain tolerance to ischemia was determined by measuring and evaluating RP (∆rSO2) and cerebral oxygenation (rSO2) during a trial clamping of the carotid artery. Depending on the degree of reduction of cerebral oxygenation from the baseline (∆rSO2) during a trial clamping of the carotid artery, patients were divided into 3 groups: the first group (n = 35) - ∆rSO2 <9.9%, the second group (n = 35) - ∆rSO2 from 10 to 19.9%, the third group (n = 14) - ∆rSO2 ≥ 20%. The primary end-point of the study was to obtain the AUC value exceeding 0.70, which could mean a high predictive quality of research methods. <br /><strong>Results:</strong> There were no perioperative strokes or myocardial infarctions during the study. Average time of carotid artery clamping was 28 (26-30) minutes. 3 patients who received temporary shunts were excluded from the study because of a simultaneous decrease in the rSO2 and ∆rSO2 indicators. It was found out that S-100 and NSE protein concentration in all groups did not significantly differ at different stages (p> 0.05). A temporary shutdown of blood flow in the carotid artery during CEA is accompanied by significant elevation of cerebral damage markers (S100, NSE) concentration with their subsequent restoration at 3 days after surgery. ROC - analysis revealed that none of the methods for assessing cerebral ischemic tolerance (RP, ∆rSO2 and rSO2) is precise enough (AUC > 0.7) to predict brain injury during carotid endarterectomy. Satisfactory, but a poor quality (AUC< 0.7) of predicting an increase in the reference values of S-100 protein neuromarkers was demonstrated by retrograde pressure, while the other indicators (∆rSO2 and rSO2) did not exceed the area under the curve (AUC) over 0.60. <br /><strong>Conclusion:</strong> Methods of measuring retrograde pressure and cerebral oxygenation are merely a reflection of the collateral blood flow and the cerebral oxygenation level due to their close relationship, but they cannot be used as predictors of ischemic neuronal damage during carotid endarterectomy because of poor predictive quality.</p> |
| first_indexed | 2024-03-12T08:30:58Z |
| format | Article |
| id | doaj.art-7f17d2424387421aae39cb2ace9df85d |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T08:30:58Z |
| publishDate | 2016-08-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-7f17d2424387421aae39cb2ace9df85d2023-09-02T17:41:27ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192016-08-012029510310.21688/1681-3472-2016-2-95-1031034The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomyА. А. Карпенко0Р. А. Кужугет1О. В. Каменская2П. В. Игнатенко3В. Б. Стародубцев4А. Н. Шилова5Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15<p><strong>Aim:</strong> The study aimed to determine the predictive value of retrograde pressure (RP) indicators and cerebral oxygenation in the evaluation of ischemic brain damage during carotid endarterectomy (CEA).<br /><strong>Methods:</strong> This nonrandomized, prospective pilot study included 87 patients with asymptomatic stenosis greater than 70% who underwent carotid endarterectomy under general anesthesia. Brain tolerance to ischemia was determined by measuring and evaluating RP (∆rSO2) and cerebral oxygenation (rSO2) during a trial clamping of the carotid artery. Depending on the degree of reduction of cerebral oxygenation from the baseline (∆rSO2) during a trial clamping of the carotid artery, patients were divided into 3 groups: the first group (n = 35) - ∆rSO2 <9.9%, the second group (n = 35) - ∆rSO2 from 10 to 19.9%, the third group (n = 14) - ∆rSO2 ≥ 20%. The primary end-point of the study was to obtain the AUC value exceeding 0.70, which could mean a high predictive quality of research methods. <br /><strong>Results:</strong> There were no perioperative strokes or myocardial infarctions during the study. Average time of carotid artery clamping was 28 (26-30) minutes. 3 patients who received temporary shunts were excluded from the study because of a simultaneous decrease in the rSO2 and ∆rSO2 indicators. It was found out that S-100 and NSE protein concentration in all groups did not significantly differ at different stages (p> 0.05). A temporary shutdown of blood flow in the carotid artery during CEA is accompanied by significant elevation of cerebral damage markers (S100, NSE) concentration with their subsequent restoration at 3 days after surgery. ROC - analysis revealed that none of the methods for assessing cerebral ischemic tolerance (RP, ∆rSO2 and rSO2) is precise enough (AUC > 0.7) to predict brain injury during carotid endarterectomy. Satisfactory, but a poor quality (AUC< 0.7) of predicting an increase in the reference values of S-100 protein neuromarkers was demonstrated by retrograde pressure, while the other indicators (∆rSO2 and rSO2) did not exceed the area under the curve (AUC) over 0.60. <br /><strong>Conclusion:</strong> Methods of measuring retrograde pressure and cerebral oxygenation are merely a reflection of the collateral blood flow and the cerebral oxygenation level due to their close relationship, but they cannot be used as predictors of ischemic neuronal damage during carotid endarterectomy because of poor predictive quality.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/350Каротидная эндартерэктомияЦеребральная оксигенацияРетроградное давлениеПротеин S-100Нейроспецифическая енолаза |
| spellingShingle | А. А. Карпенко Р. А. Кужугет О. В. Каменская П. В. Игнатенко В. Б. Стародубцев А. Н. Шилова The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy Патология кровообращения и кардиохирургия Каротидная эндартерэктомия Церебральная оксигенация Ретроградное давление Протеин S-100 Нейроспецифическая енолаза |
| title | The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| title_full | The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| title_fullStr | The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| title_full_unstemmed | The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| title_short | The prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| title_sort | prognostic value of cerebral oxygenation and retrograde pressure during carotid endarterectomy |
| topic | Каротидная эндартерэктомия Церебральная оксигенация Ретроградное давление Протеин S-100 Нейроспецифическая енолаза |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/350 |
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