Nanoparticle Based Cardiac Specific Drug Delivery
Heart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/12/1/82 |
| _version_ | 1827628413882466304 |
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| author | Dong Li Yura Son Michelle Jang Shu Wang Wuqiang Zhu |
| author_facet | Dong Li Yura Son Michelle Jang Shu Wang Wuqiang Zhu |
| author_sort | Dong Li |
| collection | DOAJ |
| description | Heart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles are the most commonly used vehicles for targeted drug delivery. Various nanoparticles have been synthesized to deliver drugs and other therapeutic molecules to the injured heart via passive or active targeting approaches, and their targeting specificity and therapeutic efficacies have been investigated. Here, we summarized nanoparticle-based, cardiac-specific drug delivery systems, their potency for treating heart diseases, and the mechanisms underlying these cardiac-targeting strategies. We also discussed the clinical studies that have employed nanoparticle-based cardiac-specific drug delivery. |
| first_indexed | 2024-03-09T13:32:14Z |
| format | Article |
| id | doaj.art-7f187cf896404f9ba4fa4526b7cd21fa |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T13:32:14Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-7f187cf896404f9ba4fa4526b7cd21fa2023-11-30T21:17:06ZengMDPI AGBiology2079-77372023-01-011218210.3390/biology12010082Nanoparticle Based Cardiac Specific Drug DeliveryDong Li0Yura Son1Michelle Jang2Shu Wang3Wuqiang Zhu4Department of Cardiovascular Diseases, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USADepartment of Cardiovascular Diseases, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USADepartment of Cardiovascular Diseases, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USADepartment of Cardiovascular Diseases, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USAHeart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles are the most commonly used vehicles for targeted drug delivery. Various nanoparticles have been synthesized to deliver drugs and other therapeutic molecules to the injured heart via passive or active targeting approaches, and their targeting specificity and therapeutic efficacies have been investigated. Here, we summarized nanoparticle-based, cardiac-specific drug delivery systems, their potency for treating heart diseases, and the mechanisms underlying these cardiac-targeting strategies. We also discussed the clinical studies that have employed nanoparticle-based cardiac-specific drug delivery.https://www.mdpi.com/2079-7737/12/1/82cardiactargeted deliverymyocardialischemiananomaterialnanoparticle |
| spellingShingle | Dong Li Yura Son Michelle Jang Shu Wang Wuqiang Zhu Nanoparticle Based Cardiac Specific Drug Delivery Biology cardiac targeted delivery myocardial ischemia nanomaterial nanoparticle |
| title | Nanoparticle Based Cardiac Specific Drug Delivery |
| title_full | Nanoparticle Based Cardiac Specific Drug Delivery |
| title_fullStr | Nanoparticle Based Cardiac Specific Drug Delivery |
| title_full_unstemmed | Nanoparticle Based Cardiac Specific Drug Delivery |
| title_short | Nanoparticle Based Cardiac Specific Drug Delivery |
| title_sort | nanoparticle based cardiac specific drug delivery |
| topic | cardiac targeted delivery myocardial ischemia nanomaterial nanoparticle |
| url | https://www.mdpi.com/2079-7737/12/1/82 |
| work_keys_str_mv | AT dongli nanoparticlebasedcardiacspecificdrugdelivery AT yurason nanoparticlebasedcardiacspecificdrugdelivery AT michellejang nanoparticlebasedcardiacspecificdrugdelivery AT shuwang nanoparticlebasedcardiacspecificdrugdelivery AT wuqiangzhu nanoparticlebasedcardiacspecificdrugdelivery |