The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018
Abstract Background The administration of antenatal corticosteroids (ACS) to women who are at risk of preterm birth has been proven to reduce not only the mortality, but also the major morbidities of the preterm infants. The rate of ACS and the risk factors associated with ACS use in Chinese populat...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-022-03529-2 |
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| author | Qing Wang Siyuan Jiang Xuefeng Hu Chao Chen Yun Cao Shoo Kim Lee Jiang-Qin Liu On behalf of the Reduction of Infection in Neonatal Intensive Care Units using the Evidence-based Practice for Improving Quality (REIN-EPIQ) Study Group |
| author_facet | Qing Wang Siyuan Jiang Xuefeng Hu Chao Chen Yun Cao Shoo Kim Lee Jiang-Qin Liu On behalf of the Reduction of Infection in Neonatal Intensive Care Units using the Evidence-based Practice for Improving Quality (REIN-EPIQ) Study Group |
| author_sort | Qing Wang |
| collection | DOAJ |
| description | Abstract Background The administration of antenatal corticosteroids (ACS) to women who are at risk of preterm birth has been proven to reduce not only the mortality, but also the major morbidities of the preterm infants. The rate of ACS and the risk factors associated with ACS use in Chinese population is unclear. This study aimed to investigate the rate of ACS use and the associated perinatal factors in the tertiary maternal centers of China. Methods Data for this retrospective observational study came from a clinical database of preterm infants established by REIN-EPIQ trial. All infants born at < 34 weeks of gestation and admitted to 18 tertiary maternal centers in China from 2017 to 2018 were enrolled. Any dose of dexamethasone was given prior to preterm delivery was recorded and the associated perinatal factors were analyzed. Results The rate of ACS exposure in this population was 71.2% (range 20.2 – 92%) and the ACS use in these 18 maternal centers varied from 20.2 to 92.0% in this period. ACS exposure was higher among women with preeclampsia, caesarean section delivery, antibiotic treatment and who delivered infants with lower gestational age and small for gestational age. ACS use was highest in the 28–31 weeks gestational age group, and lowest in the under 26 weeks of gestational age group (x2 = 65.478, P < 0.001). ACS exposure was associated with lower odds of bronchopulmonary dysplasia or death (OR, 0.778; 95% CI 0.661 to 0.916) and invasive respiration requirement (OR, 0.668; 95% CI 0.585 to 0.762) in this population. Conclusion The ACS exposure was variable among maternity hospitals and quality improvement of ACS administration is warranted. |
| first_indexed | 2024-04-11T21:35:54Z |
| format | Article |
| id | doaj.art-7f193efcff274722a0c9318db76c8083 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-11T21:35:54Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-7f193efcff274722a0c9318db76c80832022-12-22T04:01:46ZengBMCBMC Pediatrics1471-24312022-08-012211810.1186/s12887-022-03529-2The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018Qing Wang0Siyuan Jiang1Xuefeng Hu2Chao Chen3Yun Cao4Shoo Kim Lee5Jiang-Qin Liu6On behalf of the Reduction of Infection in Neonatal Intensive Care Units using the Evidence-based Practice for Improving Quality (REIN-EPIQ) Study GroupDepartment of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of MedicineDepartment of Neonatology, Children’s Hospital of Fudan UniversityDepartment of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of MedicineDepartment of Neonatology, Children’s Hospital of Fudan UniversityDepartment of Neonatology, Children’s Hospital of Fudan UniversityMaternal-Infant Care Research Centre and Department of Pediatrics Mount Sinai Hospital, Department of Pediatrics, and #Department of Obstetrics and Gynecology and Dalla Lana School of Public Health, University of TorontoDepartment of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of MedicineAbstract Background The administration of antenatal corticosteroids (ACS) to women who are at risk of preterm birth has been proven to reduce not only the mortality, but also the major morbidities of the preterm infants. The rate of ACS and the risk factors associated with ACS use in Chinese population is unclear. This study aimed to investigate the rate of ACS use and the associated perinatal factors in the tertiary maternal centers of China. Methods Data for this retrospective observational study came from a clinical database of preterm infants established by REIN-EPIQ trial. All infants born at < 34 weeks of gestation and admitted to 18 tertiary maternal centers in China from 2017 to 2018 were enrolled. Any dose of dexamethasone was given prior to preterm delivery was recorded and the associated perinatal factors were analyzed. Results The rate of ACS exposure in this population was 71.2% (range 20.2 – 92%) and the ACS use in these 18 maternal centers varied from 20.2 to 92.0% in this period. ACS exposure was higher among women with preeclampsia, caesarean section delivery, antibiotic treatment and who delivered infants with lower gestational age and small for gestational age. ACS use was highest in the 28–31 weeks gestational age group, and lowest in the under 26 weeks of gestational age group (x2 = 65.478, P < 0.001). ACS exposure was associated with lower odds of bronchopulmonary dysplasia or death (OR, 0.778; 95% CI 0.661 to 0.916) and invasive respiration requirement (OR, 0.668; 95% CI 0.585 to 0.762) in this population. Conclusion The ACS exposure was variable among maternity hospitals and quality improvement of ACS administration is warranted.https://doi.org/10.1186/s12887-022-03529-2Antenatal corticosteroidsPretermPerinatal factorsNeonatal mortalityBronchopulmonary dysplasia |
| spellingShingle | Qing Wang Siyuan Jiang Xuefeng Hu Chao Chen Yun Cao Shoo Kim Lee Jiang-Qin Liu On behalf of the Reduction of Infection in Neonatal Intensive Care Units using the Evidence-based Practice for Improving Quality (REIN-EPIQ) Study Group The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 BMC Pediatrics Antenatal corticosteroids Preterm Perinatal factors Neonatal mortality Bronchopulmonary dysplasia |
| title | The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 |
| title_full | The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 |
| title_fullStr | The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 |
| title_full_unstemmed | The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 |
| title_short | The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018 |
| title_sort | variation of antenatal corticosteroids administration for the singleton preterm birth in china 2017 to 2018 |
| topic | Antenatal corticosteroids Preterm Perinatal factors Neonatal mortality Bronchopulmonary dysplasia |
| url | https://doi.org/10.1186/s12887-022-03529-2 |
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