A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study
Abstract Introduction This study aimed to test the efficacy of a nutritional blend (NB) in improving nutritional biomarkers and preventing cognitive decline among older adults. Methods A 1‐year randomized, double‐blind, multicenter, placebo‐controlled trial with 362 adults (58.6% female, mean 78.3 y...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12314 |
| _version_ | 1797948993151434752 |
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| author | Kelly V. Giudici Sophie Guyonnet Christelle Cantet Philipe deSouto Barreto Michael W. Weiner Duygu Tosun Corina Boschat Julie Hudry Sandrine Andrieu Bruno Vellas Jeroen A. J. Schmitt for the Nolan/DSA group |
| author_facet | Kelly V. Giudici Sophie Guyonnet Christelle Cantet Philipe deSouto Barreto Michael W. Weiner Duygu Tosun Corina Boschat Julie Hudry Sandrine Andrieu Bruno Vellas Jeroen A. J. Schmitt for the Nolan/DSA group |
| author_sort | Kelly V. Giudici |
| collection | DOAJ |
| description | Abstract Introduction This study aimed to test the efficacy of a nutritional blend (NB) in improving nutritional biomarkers and preventing cognitive decline among older adults. Methods A 1‐year randomized, double‐blind, multicenter, placebo‐controlled trial with 362 adults (58.6% female, mean 78.3 years, SD = 4.8) receiving an NB or placebo. Erythrocyte ω‐3 index and homocysteine concentrations were primary outcomes. Other outcomes included Patient‐Reported Outcomes Measurement Information System (PROMIS) Applied Cognition‐Abilities, composite cognitive score (CCS), Cognitive Function Instrument (CFI) self‐assessment and study partner, hippocampal volume (HV), and Alzheimer's disease signature cortical thickness (CT). Results A total of 305 subjects completed the follow‐up. Supplementation increased ω‐3 index and decreased homocysteine, but did not affect CCS, CFI self‐assessment, HV, and CT. Placebo improved and treatment did not change PROMIS at 1 month. Intervention showed a positive effect on CFI study partner. Discussion Although improving nutritional biomarkers, this 1‐year trial with a multi‐nutrient novel approach was not able to show effects on cognitive outcomes among older adults. |
| first_indexed | 2024-04-10T21:52:19Z |
| format | Article |
| id | doaj.art-7f1c2f08bbb54f7ea7ba5c374da4206b |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:52:19Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-7f1c2f08bbb54f7ea7ba5c374da4206b2023-01-18T11:41:04ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12314A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan StudyKelly V. Giudici0Sophie Guyonnet1Christelle Cantet2Philipe deSouto Barreto3Michael W. Weiner4Duygu Tosun5Corina Boschat6Julie Hudry7Sandrine Andrieu8Bruno Vellas9Jeroen A. J. Schmitt10for the Nolan/DSA groupGerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse) Toulouse FranceGerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse) Toulouse FranceGerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse) Toulouse FranceGerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse) Toulouse FranceDepartment of Veterans Affairs Medical Center San Francisco California USADepartment of Veterans Affairs Medical Center San Francisco California USASociété des Produits Nestlé SA Nestlé Research Lausanne SwitzerlandSociété des Produits Nestlé SA Nestlé Research Lausanne SwitzerlandCERPOP UMR1295 University of Toulouse III Inserm UPS Toulouse FranceGerontopole of Toulouse Institute of Aging Toulouse University Hospital (CHU Toulouse) Toulouse FranceSociété des Produits Nestlé SA Nestlé Research Lausanne SwitzerlandAbstract Introduction This study aimed to test the efficacy of a nutritional blend (NB) in improving nutritional biomarkers and preventing cognitive decline among older adults. Methods A 1‐year randomized, double‐blind, multicenter, placebo‐controlled trial with 362 adults (58.6% female, mean 78.3 years, SD = 4.8) receiving an NB or placebo. Erythrocyte ω‐3 index and homocysteine concentrations were primary outcomes. Other outcomes included Patient‐Reported Outcomes Measurement Information System (PROMIS) Applied Cognition‐Abilities, composite cognitive score (CCS), Cognitive Function Instrument (CFI) self‐assessment and study partner, hippocampal volume (HV), and Alzheimer's disease signature cortical thickness (CT). Results A total of 305 subjects completed the follow‐up. Supplementation increased ω‐3 index and decreased homocysteine, but did not affect CCS, CFI self‐assessment, HV, and CT. Placebo improved and treatment did not change PROMIS at 1 month. Intervention showed a positive effect on CFI study partner. Discussion Although improving nutritional biomarkers, this 1‐year trial with a multi‐nutrient novel approach was not able to show effects on cognitive outcomes among older adults.https://doi.org/10.1002/trc2.12314clinical trialscognitionhomocysteinenutritionolder adultsomega‐3 |
| spellingShingle | Kelly V. Giudici Sophie Guyonnet Christelle Cantet Philipe deSouto Barreto Michael W. Weiner Duygu Tosun Corina Boschat Julie Hudry Sandrine Andrieu Bruno Vellas Jeroen A. J. Schmitt for the Nolan/DSA group A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study Alzheimer’s & Dementia: Translational Research & Clinical Interventions clinical trials cognition homocysteine nutrition older adults omega‐3 |
| title | A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study |
| title_full | A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study |
| title_fullStr | A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study |
| title_full_unstemmed | A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study |
| title_short | A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study |
| title_sort | 1 year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community dwelling older adults the nolan study |
| topic | clinical trials cognition homocysteine nutrition older adults omega‐3 |
| url | https://doi.org/10.1002/trc2.12314 |
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