Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway

Liver fibrosis is a repair response process after chronic liver injury. During this process, activated hepatic stellate cells (HSCs) will migrate to the injury site and secrete extracellular matrix (ECM) to produce fibrous scars. Clearing activated HSCs may be a major strategy for the treatment of l...

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Bibliographic Details
Main Authors: Sumin Sun, Sheng Huan, Zhanghao Li, Yue Yao, Ying Su, Siwei Xia, Shijun Wang, Xuefen Xu, Jiangjuan Shao, Zili Zhang, Feng Zhang, Jinbo Fu, Shizhong Zheng
Format: Article
Language:English
Published: PeerJ Inc. 2022-05-01
Series:PeerJ
Subjects:
Curcumol
Necroptosis
ER stress
Sirt1
NICD
Liver fibrosis
Online Access:https://peerj.com/articles/13376.pdf

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