Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma

Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma

Metformin is a drug that has been applied in clinical use for many years for the treatment of type 2 diabetes mellitus (T2DM). It achieves its function through multiple targets and modulation of multiple signaling pathways. To date, the mechanism of the action of metformin is still not fully underst...

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Bibliographic Details
Main Authors: Hui Peng, Mei Hou, Zixin Wu, Jing Wang, Man Zhou, Xiangjin Zhuang, Jiayu Xing, Qianqian Tao, Long Huang, Fuhai Zhou, Shengming Zhang, Qiyu Feng, Yilin Hou, Qinsheng Yu
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Heliyon
Subjects:
Exosome
Type 2 diabetes
Hepatocellular carcinoma
miR-122
Metformin
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022027918

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