Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats
Background: Gestational infections induced inflammation (GIII) is a cause of various postnatal neurological deficits in developing countries. Such intra uterine insults could result in persistent learning-memory disabilities. There are no studies elucidating the efficacy of adolescence exercise...
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JCDR Research and Publications Private Limited
2015-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6020/12565_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Rajesh Thangarajan Ramesh Rao Tantradi Kiranmai. S. Rai Sivakumar Gopalakrishnan Vivek Perumal |
| author_facet | Rajesh Thangarajan Ramesh Rao Tantradi Kiranmai. S. Rai Sivakumar Gopalakrishnan Vivek Perumal |
| author_sort | Rajesh Thangarajan |
| collection | DOAJ |
| description | Background: Gestational infections induced inflammation
(GIII) is a cause of various postnatal neurological deficits in
developing countries. Such intra uterine insults could result in
persistent learning-memory disabilities. There are no studies
elucidating the efficacy of adolescence exercise on spatial
learning- memory abilities of young adult rats pre-exposed to
inflammatory insult during fetal life.
Aims and Objectives: The present study addresses the
efficacy of physical (running) exercise during adolescent period
in attenuating spatial memory deficits induced by exposure to
GIII in rats.
Materials and Methods: Pregnant Wistar dams were randomly
divided into control and lipopolysaccharide (LPS) groups, injected
intra peritoneally (i.p) with saline (0.5ml) or lipopolysaccharide
(LPS) (0.5mg/kg) on alternate days from gestation day 14
(GD 14) till delivery. After parturition, pups were divided into
3 groups (n=6/group) a) Sham control and LPS group divided
into 2 subgroups- b) LPS and c) LPS exercise group. Running
exercise was given only to LPS exercise group during postnatal
days (PNDs) 30 to 60 (15min/day). Spatial learning and memory
performance was assessed by Morris water maze test (MWM),
on postnatal day 61 to 67 in all groups.
Results: Young rats pre-exposed to GIII and subjected to
running exercise through juvenile period displayed significant
decrease in latency to reach escape platform and spent
significant duration in target quadrant in MWM test, compared
to age matched LPS group. Results of the current study
demonstrated that exercise through juvenile/adolescent period
effectively mitigates gestational inflammation-induced cognitive
deficits in young adult rats.
Conclusion: Inflammation during gestation impairs offspring’s
spatial memory and learning abilities. Whereas, early postnatal
physical exercise attenuates, to higher extent, cognitive
impairment resulted from exposure to LPS induced inflammation
during intrauterine growth period. |
| first_indexed | 2024-12-14T22:49:59Z |
| format | Article |
| id | doaj.art-7f1e3cfb201841d4b2c83eea7e182b63 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T22:49:59Z |
| publishDate | 2015-06-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7f1e3cfb201841d4b2c83eea7e182b632022-12-21T22:44:45ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-06-0196CF01CF0410.7860/JCDR/2015/12565.6020Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile RatsRajesh Thangarajan0Ramesh Rao Tantradi1Kiranmai. S. Rai2Sivakumar Gopalakrishnan3Vivek Perumal4Lecturer, Department of Anatomy, Melaka Manipal Medical College,Manipal University, Manipal,Udupi- Dist,Karnataka, India. Professor, Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal,Udupi- Dist, Karnataka, India. Professor, Department of Physiology, Melaka Manipal Medical College,Manipal University, Manipal, Udupi- Dist, Karnataka, India. Lecturer, Department of Physiology, Kasturba Medical College, Manipal University, Manipal, Udupi- Dist, Karnataka, India.Professional Practice Fellow, Department of Anatomy, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.Background: Gestational infections induced inflammation (GIII) is a cause of various postnatal neurological deficits in developing countries. Such intra uterine insults could result in persistent learning-memory disabilities. There are no studies elucidating the efficacy of adolescence exercise on spatial learning- memory abilities of young adult rats pre-exposed to inflammatory insult during fetal life. Aims and Objectives: The present study addresses the efficacy of physical (running) exercise during adolescent period in attenuating spatial memory deficits induced by exposure to GIII in rats. Materials and Methods: Pregnant Wistar dams were randomly divided into control and lipopolysaccharide (LPS) groups, injected intra peritoneally (i.p) with saline (0.5ml) or lipopolysaccharide (LPS) (0.5mg/kg) on alternate days from gestation day 14 (GD 14) till delivery. After parturition, pups were divided into 3 groups (n=6/group) a) Sham control and LPS group divided into 2 subgroups- b) LPS and c) LPS exercise group. Running exercise was given only to LPS exercise group during postnatal days (PNDs) 30 to 60 (15min/day). Spatial learning and memory performance was assessed by Morris water maze test (MWM), on postnatal day 61 to 67 in all groups. Results: Young rats pre-exposed to GIII and subjected to running exercise through juvenile period displayed significant decrease in latency to reach escape platform and spent significant duration in target quadrant in MWM test, compared to age matched LPS group. Results of the current study demonstrated that exercise through juvenile/adolescent period effectively mitigates gestational inflammation-induced cognitive deficits in young adult rats. Conclusion: Inflammation during gestation impairs offspring’s spatial memory and learning abilities. Whereas, early postnatal physical exercise attenuates, to higher extent, cognitive impairment resulted from exposure to LPS induced inflammation during intrauterine growth period.https://jcdr.net/articles/PDF/6020/12565_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfcognitive deficitslipopolysaccharidesprenatal inflammationrunning exercise |
| spellingShingle | Rajesh Thangarajan Ramesh Rao Tantradi Kiranmai. S. Rai Sivakumar Gopalakrishnan Vivek Perumal Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats Journal of Clinical and Diagnostic Research cognitive deficits lipopolysaccharides prenatal inflammation running exercise |
| title | Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats |
| title_full | Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats |
| title_fullStr | Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats |
| title_full_unstemmed | Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats |
| title_short | Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats |
| title_sort | inflammation during gestation induced spatial memory and learning deficits attenuated by physical exercise in juvenile rats |
| topic | cognitive deficits lipopolysaccharides prenatal inflammation running exercise |
| url | https://jcdr.net/articles/PDF/6020/12565_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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