Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adaptation. We tested if evolved bacterial resistance...

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Bibliographic Details
Main Authors: Brittany Rosener, Serkan Sayin, Peter O Oluoch, Aurian P García González, Hirotada Mori, Albertha JM Walhout, Amir Mitchell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
evolutionary adaptation
chemotherapy
microbiome
drug resistance
drug adaptation
Online Access:https://elifesciences.org/articles/59831

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