Myeloperoxidase, modified lipoproteins, and atherogenesis
Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These fac...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-01-01
|
| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520306374 |
| _version_ | 1818740400765009920 |
|---|---|
| author | Stephen J. Nicholls Stanley L. Hazen |
| author_facet | Stephen J. Nicholls Stanley L. Hazen |
| author_sort | Stephen J. Nicholls |
| collection | DOAJ |
| description | Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO and its oxidation products predict increased cardiovascular risk. As a result, interest has focused on the potential to target MPO for the development of new risk markers, imaging, and therapies to prevent cardiovascular events. |
| first_indexed | 2024-12-18T01:40:08Z |
| format | Article |
| id | doaj.art-7f1ecdb0bfa04717b7436f1280603e9b |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T01:40:08Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-7f1ecdb0bfa04717b7436f1280603e9b2022-12-21T21:25:21ZengElsevierJournal of Lipid Research0022-22752009-01-0150S346S351Myeloperoxidase, modified lipoproteins, and atherogenesisStephen J. Nicholls0Stanley L. Hazen1Departments of Cell Biology and Cardiovascular Medicine, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OHTo whom correspondence should be addressed; Departments of Cell Biology and Cardiovascular Medicine, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OHNumerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO and its oxidation products predict increased cardiovascular risk. As a result, interest has focused on the potential to target MPO for the development of new risk markers, imaging, and therapies to prevent cardiovascular events.http://www.sciencedirect.com/science/article/pii/S0022227520306374oxidant stressfree radicalsscavenger receptorhigh density lipoprotein |
| spellingShingle | Stephen J. Nicholls Stanley L. Hazen Myeloperoxidase, modified lipoproteins, and atherogenesis Journal of Lipid Research oxidant stress free radicals scavenger receptor high density lipoprotein |
| title | Myeloperoxidase, modified lipoproteins, and atherogenesis |
| title_full | Myeloperoxidase, modified lipoproteins, and atherogenesis |
| title_fullStr | Myeloperoxidase, modified lipoproteins, and atherogenesis |
| title_full_unstemmed | Myeloperoxidase, modified lipoproteins, and atherogenesis |
| title_short | Myeloperoxidase, modified lipoproteins, and atherogenesis |
| title_sort | myeloperoxidase modified lipoproteins and atherogenesis |
| topic | oxidant stress free radicals scavenger receptor high density lipoprotein |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520306374 |
| work_keys_str_mv | AT stephenjnicholls myeloperoxidasemodifiedlipoproteinsandatherogenesis AT stanleylhazen myeloperoxidasemodifiedlipoproteinsandatherogenesis |