Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications
Nucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers’ research and development for biomedicine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/11/527 |
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| author | Elizaveta A. Shatunova Maksim A. Korolev Vitaly O. Omelchenko Yuliya D. Kurochkina Anna S. Davydova Alya G. Venyaminova Mariya A. Vorobyeva |
| author_facet | Elizaveta A. Shatunova Maksim A. Korolev Vitaly O. Omelchenko Yuliya D. Kurochkina Anna S. Davydova Alya G. Venyaminova Mariya A. Vorobyeva |
| author_sort | Elizaveta A. Shatunova |
| collection | DOAJ |
| description | Nucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers’ research and development for biomedicine is made on cardiovascular, infectious, and malignant diseases, the use of aptamers as therapeutic or diagnostic tools in the context of rheumatic diseases is no less important. In this review, we consider the main features of aptamers that make them valuable molecular tools for rheumatologists, and summarize the studies on the selection and application of aptamers for protein biomarkers associated with rheumatic diseases. We discuss the progress in the development of aptamer-based diagnostic assays and targeted therapeutics for rheumatic disorders, future prospects in the field, and issues that have yet to be addressed. |
| first_indexed | 2024-03-10T14:40:01Z |
| format | Article |
| id | doaj.art-7f1f901940a34ee496bb7379ea144b30 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:40:01Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7f1f901940a34ee496bb7379ea144b302023-11-20T21:52:47ZengMDPI AGBiomedicines2227-90592020-11-0181152710.3390/biomedicines8110527Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic ApplicationsElizaveta A. Shatunova0Maksim A. Korolev1Vitaly O. Omelchenko2Yuliya D. Kurochkina3Anna S. Davydova4Alya G. Venyaminova5Mariya A. Vorobyeva6Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090 Novosibirsk, RussiaResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630060 Novosibirsk, RussiaResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630060 Novosibirsk, RussiaResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630060 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090 Novosibirsk, RussiaNucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers’ research and development for biomedicine is made on cardiovascular, infectious, and malignant diseases, the use of aptamers as therapeutic or diagnostic tools in the context of rheumatic diseases is no less important. In this review, we consider the main features of aptamers that make them valuable molecular tools for rheumatologists, and summarize the studies on the selection and application of aptamers for protein biomarkers associated with rheumatic diseases. We discuss the progress in the development of aptamer-based diagnostic assays and targeted therapeutics for rheumatic disorders, future prospects in the field, and issues that have yet to be addressed.https://www.mdpi.com/2227-9059/8/11/527aptamersrheumatic diseasesprotein biomarkersaptasensorsaptamer therapeutics |
| spellingShingle | Elizaveta A. Shatunova Maksim A. Korolev Vitaly O. Omelchenko Yuliya D. Kurochkina Anna S. Davydova Alya G. Venyaminova Mariya A. Vorobyeva Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications Biomedicines aptamers rheumatic diseases protein biomarkers aptasensors aptamer therapeutics |
| title | Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications |
| title_full | Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications |
| title_fullStr | Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications |
| title_full_unstemmed | Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications |
| title_short | Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications |
| title_sort | aptamers for proteins associated with rheumatic diseases progress challenges and prospects of diagnostic and therapeutic applications |
| topic | aptamers rheumatic diseases protein biomarkers aptasensors aptamer therapeutics |
| url | https://www.mdpi.com/2227-9059/8/11/527 |
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