Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid
Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a compone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/18/8591 |
| _version_ | 1797520329865691136 |
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| author | Jae Hyuk Choi Donghee Son Mikyung Shin |
| author_facet | Jae Hyuk Choi Donghee Son Mikyung Shin |
| author_sort | Jae Hyuk Choi |
| collection | DOAJ |
| description | Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexation and its adhesive gelation for complete tissue sealing without additional suturing. The polysaccharide adhesive suture threads demonstrated long-term stability, which is useful when used for skin wound suturing. Specifically, their robust adhesion property occurred as soon as the threads were soaked, attaining a swollen hydrogel state, dependent on the presence of body fluids after suturing. Moreover, the pH of the body fluids affects the viscoelasticity and adhesiveness of the hydrogels in order to ensure a tight sealing. Therefore, we expect that these pH-responsive adhesive threads would be promising for the development of on-demand functional suture materials. |
| first_indexed | 2024-03-10T07:55:13Z |
| format | Article |
| id | doaj.art-7f1fc01dd7414cfd9a627f995c3cf0f4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T07:55:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-7f1fc01dd7414cfd9a627f995c3cf0f42023-11-22T11:55:13ZengMDPI AGApplied Sciences2076-34172021-09-011118859110.3390/app11188591Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic AcidJae Hyuk Choi0Donghee Son1Mikyung Shin2Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Seobu-ro 2066, Jangan-gu, Suwon 16419, KoreaDepartment of Electrical and Computer Engineering, Sungkyunkwan University (SKKU), Seobu-ro 2066, Jangan-gu, Suwon 16419, KoreaDepartment of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Seobu-ro 2066, Jangan-gu, Suwon 16419, KoreaAdhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexation and its adhesive gelation for complete tissue sealing without additional suturing. The polysaccharide adhesive suture threads demonstrated long-term stability, which is useful when used for skin wound suturing. Specifically, their robust adhesion property occurred as soon as the threads were soaked, attaining a swollen hydrogel state, dependent on the presence of body fluids after suturing. Moreover, the pH of the body fluids affects the viscoelasticity and adhesiveness of the hydrogels in order to ensure a tight sealing. Therefore, we expect that these pH-responsive adhesive threads would be promising for the development of on-demand functional suture materials.https://www.mdpi.com/2076-3417/11/18/8591bioadhesivehydrogel threadspH responsiveness |
| spellingShingle | Jae Hyuk Choi Donghee Son Mikyung Shin Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid Applied Sciences bioadhesive hydrogel threads pH responsiveness |
| title | Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid |
| title_full | Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid |
| title_fullStr | Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid |
| title_full_unstemmed | Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid |
| title_short | Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid |
| title_sort | sundew inspired adhesive hydrogel threads through reversible complexation of polyphenol and boronic acid |
| topic | bioadhesive hydrogel threads pH responsiveness |
| url | https://www.mdpi.com/2076-3417/11/18/8591 |
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