Long COVID: Is there a kidney link?
Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1138644/full |
| _version_ | 1797854141283827712 |
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| author | Raymond E. Garrett Carlos H. Palacio David Bar-Or David Bar-Or |
| author_facet | Raymond E. Garrett Carlos H. Palacio David Bar-Or David Bar-Or |
| author_sort | Raymond E. Garrett |
| collection | DOAJ |
| description | Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular injury as it may contribute to Long COVID symptoms. We propose three potential mechanisms that could be involved in Long COVID namely creatine phosphate metabolism, un-reclaimed glomerular filtrate and COVID specific proximal tubule cells (PTC) injury-a tryptophan paradigm. This approach is intended to allow for improved diagnostics and therapy for the long-haul sufferers. |
| first_indexed | 2024-04-09T20:02:05Z |
| format | Article |
| id | doaj.art-7f212e0e98c14c21924a55e57d99667e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T20:02:05Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7f212e0e98c14c21924a55e57d99667e2023-04-03T04:27:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-04-011010.3389/fmed.2023.11386441138644Long COVID: Is there a kidney link?Raymond E. Garrett0Carlos H. Palacio1David Bar-Or2David Bar-Or3Swedish Medical Center, Trauma Research Dept., Englewood, CO, United StatesSouth Texas Health System, Trauma Research Dept., McAllen, TX, United StatesSwedish Medical Center, Trauma Research Dept., Englewood, CO, United StatesSouth Texas Health System, Trauma Research Dept., McAllen, TX, United StatesMetabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular injury as it may contribute to Long COVID symptoms. We propose three potential mechanisms that could be involved in Long COVID namely creatine phosphate metabolism, un-reclaimed glomerular filtrate and COVID specific proximal tubule cells (PTC) injury-a tryptophan paradigm. This approach is intended to allow for improved diagnostics and therapy for the long-haul sufferers.https://www.frontiersin.org/articles/10.3389/fmed.2023.1138644/fullSARS-CoV-2 (COVID 19)kynurenine (KYN)creatine phosphate (CP)glomerular reclamationproximal tubule celllong COVID |
| spellingShingle | Raymond E. Garrett Carlos H. Palacio David Bar-Or David Bar-Or Long COVID: Is there a kidney link? Frontiers in Medicine SARS-CoV-2 (COVID 19) kynurenine (KYN) creatine phosphate (CP) glomerular reclamation proximal tubule cell long COVID |
| title | Long COVID: Is there a kidney link? |
| title_full | Long COVID: Is there a kidney link? |
| title_fullStr | Long COVID: Is there a kidney link? |
| title_full_unstemmed | Long COVID: Is there a kidney link? |
| title_short | Long COVID: Is there a kidney link? |
| title_sort | long covid is there a kidney link |
| topic | SARS-CoV-2 (COVID 19) kynurenine (KYN) creatine phosphate (CP) glomerular reclamation proximal tubule cell long COVID |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1138644/full |
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