Continuous Inertial Focusing and Separation of Particles by Shape
An effective approach to separating shaped particles is needed to isolate disease-causing cells for diagnostics or to aid in purifying nonspherical particles in applications ranging from food science to drug delivery. However, the separation of shaped particles is generally challenging, since nonsph...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2012-09-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.2.031017 |
| _version_ | 1818924752870309888 |
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| author | Mahdokht Masaeli Elodie Sollier Hamed Amini Wenbin Mao Kathryn Camacho Nishit Doshi Samir Mitragotri Alexander Alexeev Dino Di Carlo |
| author_facet | Mahdokht Masaeli Elodie Sollier Hamed Amini Wenbin Mao Kathryn Camacho Nishit Doshi Samir Mitragotri Alexander Alexeev Dino Di Carlo |
| author_sort | Mahdokht Masaeli |
| collection | DOAJ |
| description | An effective approach to separating shaped particles is needed to isolate disease-causing cells for diagnostics or to aid in purifying nonspherical particles in applications ranging from food science to drug delivery. However, the separation of shaped particles is generally challenging, since nonspherical particles can freely rotate and present different faces while being sorted. We experimentally and numerically show that inertial fluid-dynamic effects allow for shape-dependent separation of flowing particles. (Spheres and rods with aspect ratios of 3∶1 and 5∶1 have all been separable.) Particle rotation around a conserved axis following Jeffery orbits is found to be a necessary component in producing different equilibrium positions across the channel that depend on particle rotational diameter. These differences are large enough to enable passive, continuous, high-purity, high-throughput, and shape-based separation downstream. Furthermore, we show that this shape-based separation can be applied to a large range of particle sizes and types, including small, artificially made 3-μm particles as well as bioparticles such as yeast. This practical approach for sorting particles by a previously inaccessible geometric parameter opens up a new capability that should find use in a range of fields. |
| first_indexed | 2024-12-20T02:30:20Z |
| format | Article |
| id | doaj.art-7f2130101f2347bf9b95f9d9ab6a7f86 |
| institution | Directory Open Access Journal |
| issn | 2160-3308 |
| language | English |
| last_indexed | 2024-12-20T02:30:20Z |
| publishDate | 2012-09-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review X |
| spelling | doaj.art-7f2130101f2347bf9b95f9d9ab6a7f862022-12-21T19:56:35ZengAmerican Physical SocietyPhysical Review X2160-33082012-09-012303101710.1103/PhysRevX.2.031017Continuous Inertial Focusing and Separation of Particles by ShapeMahdokht MasaeliElodie SollierHamed AminiWenbin MaoKathryn CamachoNishit DoshiSamir MitragotriAlexander AlexeevDino Di CarloAn effective approach to separating shaped particles is needed to isolate disease-causing cells for diagnostics or to aid in purifying nonspherical particles in applications ranging from food science to drug delivery. However, the separation of shaped particles is generally challenging, since nonspherical particles can freely rotate and present different faces while being sorted. We experimentally and numerically show that inertial fluid-dynamic effects allow for shape-dependent separation of flowing particles. (Spheres and rods with aspect ratios of 3∶1 and 5∶1 have all been separable.) Particle rotation around a conserved axis following Jeffery orbits is found to be a necessary component in producing different equilibrium positions across the channel that depend on particle rotational diameter. These differences are large enough to enable passive, continuous, high-purity, high-throughput, and shape-based separation downstream. Furthermore, we show that this shape-based separation can be applied to a large range of particle sizes and types, including small, artificially made 3-μm particles as well as bioparticles such as yeast. This practical approach for sorting particles by a previously inaccessible geometric parameter opens up a new capability that should find use in a range of fields.http://doi.org/10.1103/PhysRevX.2.031017 |
| spellingShingle | Mahdokht Masaeli Elodie Sollier Hamed Amini Wenbin Mao Kathryn Camacho Nishit Doshi Samir Mitragotri Alexander Alexeev Dino Di Carlo Continuous Inertial Focusing and Separation of Particles by Shape Physical Review X |
| title | Continuous Inertial Focusing and Separation of Particles by Shape |
| title_full | Continuous Inertial Focusing and Separation of Particles by Shape |
| title_fullStr | Continuous Inertial Focusing and Separation of Particles by Shape |
| title_full_unstemmed | Continuous Inertial Focusing and Separation of Particles by Shape |
| title_short | Continuous Inertial Focusing and Separation of Particles by Shape |
| title_sort | continuous inertial focusing and separation of particles by shape |
| url | http://doi.org/10.1103/PhysRevX.2.031017 |
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