Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease
Continuous infusion of levodopa or apomorphine provide constant dopaminergic stimulations are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson’s disease (PD). Apomorphine provides motor benefit similar to dopamine, but its long-term use is...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2009-05-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-2-1-4-2.pdf |
| _version_ | 1797716057390055424 |
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| author | Angelo Antonini |
| author_facet | Angelo Antonini |
| author_sort | Angelo Antonini |
| collection | DOAJ |
| description | Continuous infusion of levodopa or apomorphine provide constant dopaminergic stimulations are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson’s disease (PD). Apomorphine provides motor benefit similar to dopamine, but its long-term use is limited by compliance, mostly injection site skin reactions. Administration of levodopa/carbidopa by continuous duodenal infusion allows replacement of all oral medications and permits achievement of a satisfactory therapeutic response paralleled by a reduction in motor complication severity. However, this procedure is more invasive than apomorphine as it requires a percutaneous endoscopic gastrostomy Clinical experience with infusions shows that continuous dopaminergic stimulation of dopaminergic medications reduces dyskinesia and widens the therapeutic window in advanced PD. |
| first_indexed | 2024-03-12T08:15:53Z |
| format | Article |
| id | doaj.art-7f225422f2634d10a6bbd0e14fb20594 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:53Z |
| publishDate | 2009-05-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-7f225422f2634d10a6bbd0e14fb205942023-09-02T18:53:32ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392009-05-01214910.14802/jmd.0900290Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s DiseaseAngelo AntoniniContinuous infusion of levodopa or apomorphine provide constant dopaminergic stimulations are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson’s disease (PD). Apomorphine provides motor benefit similar to dopamine, but its long-term use is limited by compliance, mostly injection site skin reactions. Administration of levodopa/carbidopa by continuous duodenal infusion allows replacement of all oral medications and permits achievement of a satisfactory therapeutic response paralleled by a reduction in motor complication severity. However, this procedure is more invasive than apomorphine as it requires a percutaneous endoscopic gastrostomy Clinical experience with infusions shows that continuous dopaminergic stimulation of dopaminergic medications reduces dyskinesia and widens the therapeutic window in advanced PD.http://e-jmd.org/upload/jmd-2-1-4-2.pdfParkinson’s diseaseInfusionApomorphineLevodopaCarbidopaDuodopaDBS |
| spellingShingle | Angelo Antonini Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease Journal of Movement Disorders Parkinson’s disease Infusion Apomorphine Levodopa Carbidopa Duodopa DBS |
| title | Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease |
| title_full | Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease |
| title_fullStr | Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease |
| title_full_unstemmed | Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease |
| title_short | Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease |
| title_sort | apomorphine and levodopa infusion therapies for advanced parkinson s disease |
| topic | Parkinson’s disease Infusion Apomorphine Levodopa Carbidopa Duodopa DBS |
| url | http://e-jmd.org/upload/jmd-2-1-4-2.pdf |
| work_keys_str_mv | AT angeloantonini apomorphineandlevodopainfusiontherapiesforadvancedparkinsonsdisease |