A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin

BackgroundWe conducted this study to evaluate if a reduced cumulative dose of induction and concurrent cisplatin conferred similar favorable outcomes when compared to trial NPC-0501.MethodsNewly diagnosed nasopharyngeal carcinoma (NPC) with stage III-IVA were prospectively recruited from January 201...

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Main Authors: Zhiyuan Xu, Li Yang, Wai-Tong Ng, Aya El Helali, Victor Ho-Fun Lee, Lingyu Ma, Qin Liu, Jishi Li, Lin Shen, Jijie Huang, Jiandong Zha, Cheng Zhou, Anne W. M. Lee, Longhua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.842281/full
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author Zhiyuan Xu
Zhiyuan Xu
Li Yang
Wai-Tong Ng
Wai-Tong Ng
Aya El Helali
Aya El Helali
Victor Ho-Fun Lee
Victor Ho-Fun Lee
Lingyu Ma
Qin Liu
Jishi Li
Lin Shen
Jijie Huang
Jiandong Zha
Cheng Zhou
Anne W. M. Lee
Anne W. M. Lee
Longhua Chen
author_facet Zhiyuan Xu
Zhiyuan Xu
Li Yang
Wai-Tong Ng
Wai-Tong Ng
Aya El Helali
Aya El Helali
Victor Ho-Fun Lee
Victor Ho-Fun Lee
Lingyu Ma
Qin Liu
Jishi Li
Lin Shen
Jijie Huang
Jiandong Zha
Cheng Zhou
Anne W. M. Lee
Anne W. M. Lee
Longhua Chen
author_sort Zhiyuan Xu
collection DOAJ
description BackgroundWe conducted this study to evaluate if a reduced cumulative dose of induction and concurrent cisplatin conferred similar favorable outcomes when compared to trial NPC-0501.MethodsNewly diagnosed nasopharyngeal carcinoma (NPC) with stage III-IVA were prospectively recruited from January 2015 to September 2019. Induction chemotherapy (IC) consisted of cisplatin 80mg/m2 on day 1 and capecitabine 1000mg/m2 twice daily from day 1 to 14 every 3 weeks for 3 cycles followed by concurrent chemoradiotherapy (CCRT) with 2 cycles of cisplatin 100mg/m2 given every 3 weeks. Tumor response was evaluated according to RECIST v1.1. Acute and late adverse events (AEs) were graded with CTCAE v4.0 and Late Radiation Morbidity Scoring of the RTOG, respectively.Results135 patients were recruited. At 16 weeks after CCRT, all 130 patients who completed the entire course of radiotherapy (RT) had a complete response upon final assessment. With a median follow-up of 36.2 months, 22 treatment failures and 8 deaths were observed. The 3-year progression-free survival, overall survival, locoregional recurrence-free survival, and distant recurrence-free survival were 83.7%, 94.1%, 94.1%, and 85.9%, respectively. Our survival data outcomes were similar to those reported in the cisplatin and capecitabine (PX) induction arm of the 0501 trial. 103 patients (76.3%) reported acute grade 3-4 AEs. Two patients (1.5%) had late grade 3-4 complications, numerically fewer than those reported in the NPC-0501 trial.ConclusionsInduction PX and concurrent cisplatin with a reduced cumulative cisplatin dose yield survival outcomes comparable to those reported in the NPC-0501 trial with excellent tolerability. Therefore, a reduced cumulative dose of cisplatin is a promising treatment scheme for nasopharyngeal carcinoma.
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spelling doaj.art-7f22d18e4520460f9f9ee47e913589c42022-12-22T01:53:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.842281842281A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of CisplatinZhiyuan Xu0Zhiyuan Xu1Li Yang2Wai-Tong Ng3Wai-Tong Ng4Aya El Helali5Aya El Helali6Victor Ho-Fun Lee7Victor Ho-Fun Lee8Lingyu Ma9Qin Liu10Jishi Li11Lin Shen12Jijie Huang13Jiandong Zha14Cheng Zhou15Anne W. M. Lee16Anne W. M. Lee17Longhua Chen18Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong KongSAR, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong KongSAR, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong KongSAR, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaClinical Oncology Centre, The University of Hong Kong - Shenzhen Hospital, Shenzhen, ChinaDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong KongSAR, ChinaDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaBackgroundWe conducted this study to evaluate if a reduced cumulative dose of induction and concurrent cisplatin conferred similar favorable outcomes when compared to trial NPC-0501.MethodsNewly diagnosed nasopharyngeal carcinoma (NPC) with stage III-IVA were prospectively recruited from January 2015 to September 2019. Induction chemotherapy (IC) consisted of cisplatin 80mg/m2 on day 1 and capecitabine 1000mg/m2 twice daily from day 1 to 14 every 3 weeks for 3 cycles followed by concurrent chemoradiotherapy (CCRT) with 2 cycles of cisplatin 100mg/m2 given every 3 weeks. Tumor response was evaluated according to RECIST v1.1. Acute and late adverse events (AEs) were graded with CTCAE v4.0 and Late Radiation Morbidity Scoring of the RTOG, respectively.Results135 patients were recruited. At 16 weeks after CCRT, all 130 patients who completed the entire course of radiotherapy (RT) had a complete response upon final assessment. With a median follow-up of 36.2 months, 22 treatment failures and 8 deaths were observed. The 3-year progression-free survival, overall survival, locoregional recurrence-free survival, and distant recurrence-free survival were 83.7%, 94.1%, 94.1%, and 85.9%, respectively. Our survival data outcomes were similar to those reported in the cisplatin and capecitabine (PX) induction arm of the 0501 trial. 103 patients (76.3%) reported acute grade 3-4 AEs. Two patients (1.5%) had late grade 3-4 complications, numerically fewer than those reported in the NPC-0501 trial.ConclusionsInduction PX and concurrent cisplatin with a reduced cumulative cisplatin dose yield survival outcomes comparable to those reported in the NPC-0501 trial with excellent tolerability. Therefore, a reduced cumulative dose of cisplatin is a promising treatment scheme for nasopharyngeal carcinoma.https://www.frontiersin.org/articles/10.3389/fonc.2022.842281/fullnasopharyngeal carcinomainduction chemotherapycisplatincapecitabineprogression-free survival
spellingShingle Zhiyuan Xu
Zhiyuan Xu
Li Yang
Wai-Tong Ng
Wai-Tong Ng
Aya El Helali
Aya El Helali
Victor Ho-Fun Lee
Victor Ho-Fun Lee
Lingyu Ma
Qin Liu
Jishi Li
Lin Shen
Jijie Huang
Jiandong Zha
Cheng Zhou
Anne W. M. Lee
Anne W. M. Lee
Longhua Chen
A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
Frontiers in Oncology
nasopharyngeal carcinoma
induction chemotherapy
cisplatin
capecitabine
progression-free survival
title A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
title_full A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
title_fullStr A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
title_full_unstemmed A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
title_short A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin
title_sort single arm phase 2 trial on induction chemotherapy followed by concurrent chemoradiation in nasopharyngeal carcinoma using a reduced cumulative dose of cisplatin
topic nasopharyngeal carcinoma
induction chemotherapy
cisplatin
capecitabine
progression-free survival
url https://www.frontiersin.org/articles/10.3389/fonc.2022.842281/full
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