A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin

A Single-Arm Phase 2 Trial on Induction Chemotherapy Followed by Concurrent Chemoradiation in Nasopharyngeal Carcinoma Using a Reduced Cumulative Dose of Cisplatin

BackgroundWe conducted this study to evaluate if a reduced cumulative dose of induction and concurrent cisplatin conferred similar favorable outcomes when compared to trial NPC-0501.MethodsNewly diagnosed nasopharyngeal carcinoma (NPC) with stage III-IVA were prospectively recruited from January 201...

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Main Authors: Zhiyuan Xu, Li Yang, Wai-Tong Ng, Aya El Helali, Victor Ho-Fun Lee, Lingyu Ma, Qin Liu, Jishi Li, Lin Shen, Jijie Huang, Jiandong Zha, Cheng Zhou, Anne W. M. Lee, Longhua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
nasopharyngeal carcinoma
induction chemotherapy
cisplatin
capecitabine
progression-free survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.842281/full

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