Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

Abstract Background Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. A promising approach to reverse MDR is the combined use of nontoxic and potent ABC transporters inh...

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Bibliographic Details
Main Authors: Zhiqiang Zhang, Chunling Ma, Peng Li, Min Wu, Shengnan Ye, Liwu Fu, Jianhua Xu
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Cell Communication and Signaling
Subjects:
FW-04-806
ABCB1 transporter
ABCG2 transporter
Multiple drug resistance
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s12964-019-0408-5

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