In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer
With the ability of monitoring both temperature and photothermal agents, the photoacoustic (PA) imaging is a promising guiding tool for the photothermal therapy (PTT). The calibration line which depicts the relative variation of PA amplitude with the temperature should be obtained before using PA th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221359792300054X |
| _version_ | 1797801051125972992 |
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| author | Kuan Peng Yongjun Wang Lingfeng Li Jiaxi Zhang Haobin Chen Jiaying Xiao |
| author_facet | Kuan Peng Yongjun Wang Lingfeng Li Jiaxi Zhang Haobin Chen Jiaying Xiao |
| author_sort | Kuan Peng |
| collection | DOAJ |
| description | With the ability of monitoring both temperature and photothermal agents, the photoacoustic (PA) imaging is a promising guiding tool for the photothermal therapy (PTT). The calibration line which depicts the relative variation of PA amplitude with the temperature should be obtained before using PA thermometer. In existing study, a calibration line was generated based on the data from one spatial position, and used in the whole region of interesting (ROI). However, the generalization of this calibration line in ROI was not verified, especially for ROI with heterogeneous tissues. Moreover, the relationship between the distributions of photothermal agents and effective treatment area is not clear, hindering using photothermal agents’ distribution to optimize the administration-therapy interval. In this study, the distribution of effective photothermal agents and temperature in subcutaneously transplanted tumor mouse models were continuously monitored by 3D photoacoustic/ ultrasonic dual-modality imaging in 8 h after administration. With multiple micro-temperature probes in tumor and surrounding normal tissue, the PA thermometer was calibrated and evaluated at multiple spatial positions for the first time. The generalization in homologous tissue and tissue specificity in heterogeneous tissues of the PA thermometer calibration line were verified. Our study not only validated the effectivity of PA thermometer by proving the generalization of calibration line, but also removes a major obstacle that prevents applying the PA thermometer to a heterogeneous tissues ROI. The positive correlation between the proportion of effective treatment area and the proportion of effective photothermal agent area in the tumor was observed. Since the latter can be monitored with fast PA imaging, PA imaging can be employed as a convenient tool for seeking optimal administration-treatment interval. |
| first_indexed | 2024-03-13T04:44:31Z |
| format | Article |
| id | doaj.art-7f247505c884455dba84ffcce98f3e6f |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-13T04:44:31Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-7f247505c884455dba84ffcce98f3e6f2023-06-19T04:28:05ZengElsevierPhotoacoustics2213-59792023-06-0131100501In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometerKuan Peng0Yongjun Wang1Lingfeng Li2Jiaxi Zhang3Haobin Chen4Jiaying Xiao5Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China; Shenzhen Research Institute, Central South University, Shenzhen 518057, China; State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China; Corresponding author at: Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China.With the ability of monitoring both temperature and photothermal agents, the photoacoustic (PA) imaging is a promising guiding tool for the photothermal therapy (PTT). The calibration line which depicts the relative variation of PA amplitude with the temperature should be obtained before using PA thermometer. In existing study, a calibration line was generated based on the data from one spatial position, and used in the whole region of interesting (ROI). However, the generalization of this calibration line in ROI was not verified, especially for ROI with heterogeneous tissues. Moreover, the relationship between the distributions of photothermal agents and effective treatment area is not clear, hindering using photothermal agents’ distribution to optimize the administration-therapy interval. In this study, the distribution of effective photothermal agents and temperature in subcutaneously transplanted tumor mouse models were continuously monitored by 3D photoacoustic/ ultrasonic dual-modality imaging in 8 h after administration. With multiple micro-temperature probes in tumor and surrounding normal tissue, the PA thermometer was calibrated and evaluated at multiple spatial positions for the first time. The generalization in homologous tissue and tissue specificity in heterogeneous tissues of the PA thermometer calibration line were verified. Our study not only validated the effectivity of PA thermometer by proving the generalization of calibration line, but also removes a major obstacle that prevents applying the PA thermometer to a heterogeneous tissues ROI. The positive correlation between the proportion of effective treatment area and the proportion of effective photothermal agent area in the tumor was observed. Since the latter can be monitored with fast PA imaging, PA imaging can be employed as a convenient tool for seeking optimal administration-treatment interval.http://www.sciencedirect.com/science/article/pii/S221359792300054XPhotothermalPhotoacousticThermometerCalibrationImaging-guidance |
| spellingShingle | Kuan Peng Yongjun Wang Lingfeng Li Jiaxi Zhang Haobin Chen Jiaying Xiao In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer Photoacoustics Photothermal Photoacoustic Thermometer Calibration Imaging-guidance |
| title | In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer |
| title_full | In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer |
| title_fullStr | In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer |
| title_full_unstemmed | In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer |
| title_short | In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer |
| title_sort | in vivo photothermal therapy monitored by multi position calibrated photoacoustic thermometer |
| topic | Photothermal Photoacoustic Thermometer Calibration Imaging-guidance |
| url | http://www.sciencedirect.com/science/article/pii/S221359792300054X |
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