From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration
Failure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerate or replace damaged tissues and organs. In a rege...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/5/780 |
| _version_ | 1827667782264684544 |
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| author | Felicia Carotenuto Sara Politi Arsalan Ul Haq Fabio De Matteis Emanuela Tamburri Maria Letizia Terranova Laura Teodori Alessandra Pasquo Paolo Di Nardo |
| author_facet | Felicia Carotenuto Sara Politi Arsalan Ul Haq Fabio De Matteis Emanuela Tamburri Maria Letizia Terranova Laura Teodori Alessandra Pasquo Paolo Di Nardo |
| author_sort | Felicia Carotenuto |
| collection | DOAJ |
| description | Failure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerate or replace damaged tissues and organs. In a regeneration strategy, biomaterials play a key role promoting new tissue formation by providing adequate space for cell accommodation and appropriate biochemical and biophysical cues to support cell proliferation and differentiation. Among other physical cues, the architectural features of the biomaterial as a kind of instructive stimuli can influence cellular behaviors and guide cells towards a specific tissue organization. Thus, the optimization of biomaterial micro/nano architecture, through different manufacturing techniques, is a crucial strategy for a successful regenerative therapy. Over the last decades, many micro/nanostructured biomaterials have been developed to mimic the defined structure of ECM of various soft and hard tissues. This review intends to provide an overview of the relevant studies on micro/nanostructured scaffolds created for soft and hard tissue regeneration and highlights their biological effects, with a particular focus on striated muscle, cartilage, and bone tissue engineering applications. |
| first_indexed | 2024-03-10T03:24:06Z |
| format | Article |
| id | doaj.art-7f2489de3cd64f0e80a97ed1aaa8bc04 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T03:24:06Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-7f2489de3cd64f0e80a97ed1aaa8bc042023-11-23T12:13:05ZengMDPI AGMicromachines2072-666X2022-05-0113578010.3390/mi13050780From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue RegenerationFelicia Carotenuto0Sara Politi1Arsalan Ul Haq2Fabio De Matteis3Emanuela Tamburri4Maria Letizia Terranova5Laura Teodori6Alessandra Pasquo7Paolo Di Nardo8Dipartimento di Scienze Cliniche e Medicina Traslazionale, Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, ItalyDipartimento di Scienze Cliniche e Medicina Traslazionale, Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyCentro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyCentro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyCentro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, ItalyDepartment of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, ItalyDipartimento di Scienze Cliniche e Medicina Traslazionale, Università Degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyFailure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerate or replace damaged tissues and organs. In a regeneration strategy, biomaterials play a key role promoting new tissue formation by providing adequate space for cell accommodation and appropriate biochemical and biophysical cues to support cell proliferation and differentiation. Among other physical cues, the architectural features of the biomaterial as a kind of instructive stimuli can influence cellular behaviors and guide cells towards a specific tissue organization. Thus, the optimization of biomaterial micro/nano architecture, through different manufacturing techniques, is a crucial strategy for a successful regenerative therapy. Over the last decades, many micro/nanostructured biomaterials have been developed to mimic the defined structure of ECM of various soft and hard tissues. This review intends to provide an overview of the relevant studies on micro/nanostructured scaffolds created for soft and hard tissue regeneration and highlights their biological effects, with a particular focus on striated muscle, cartilage, and bone tissue engineering applications.https://www.mdpi.com/2072-666X/13/5/780micro/nanostructured biomaterialstissue regenerationarchitectural featurestissue engineeringcardiac muscular regenerationcartilage regeneration |
| spellingShingle | Felicia Carotenuto Sara Politi Arsalan Ul Haq Fabio De Matteis Emanuela Tamburri Maria Letizia Terranova Laura Teodori Alessandra Pasquo Paolo Di Nardo From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration Micromachines micro/nanostructured biomaterials tissue regeneration architectural features tissue engineering cardiac muscular regeneration cartilage regeneration |
| title | From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration |
| title_full | From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration |
| title_fullStr | From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration |
| title_full_unstemmed | From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration |
| title_short | From Soft to Hard Biomimetic Materials: Tuning Micro/Nano-Architecture of Scaffolds for Tissue Regeneration |
| title_sort | from soft to hard biomimetic materials tuning micro nano architecture of scaffolds for tissue regeneration |
| topic | micro/nanostructured biomaterials tissue regeneration architectural features tissue engineering cardiac muscular regeneration cartilage regeneration |
| url | https://www.mdpi.com/2072-666X/13/5/780 |
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