Control of Tumor Progression by Angiocrine Factors
Tumor progression, therapy resistance and metastasis are profoundly controlled by the tumor microenvironment. The contribution of endothelial cells to tumor progression was initially only attributed to the formation of new blood vessels (angiogenesis). Research in the last decade has revealed howeve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/11/2610 |
| _version_ | 1797532597916532736 |
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| author | Elisenda Alsina-Sanchis Ronja Mülfarth Andreas Fischer |
| author_facet | Elisenda Alsina-Sanchis Ronja Mülfarth Andreas Fischer |
| author_sort | Elisenda Alsina-Sanchis |
| collection | DOAJ |
| description | Tumor progression, therapy resistance and metastasis are profoundly controlled by the tumor microenvironment. The contribution of endothelial cells to tumor progression was initially only attributed to the formation of new blood vessels (angiogenesis). Research in the last decade has revealed however that endothelial cells control their microenvironment through the expression of membrane-bound and secreted factors. Such angiocrine functions are frequently hijacked by cancer cells, which deregulate the signaling pathways controlling the expression of angiocrine factors. Here, we review the crosstalk between cancer cells and endothelial cells and how this contributes to the cancer stem cell phenotype, epithelial to mesenchymal transition, immunosuppression, remodeling of the extracellular matrix and intravasation of cancer cells into the bloodstream. We also address the long-distance crosstalk of a primary tumor with endothelial cells at the pre-metastatic niche and how this contributes to metastasis. |
| first_indexed | 2024-03-10T11:01:33Z |
| format | Article |
| id | doaj.art-7f2530e51bc947bfac62eeb6aef1cb3c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:01:33Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7f2530e51bc947bfac62eeb6aef1cb3c2023-11-21T21:27:26ZengMDPI AGCancers2072-66942021-05-011311261010.3390/cancers13112610Control of Tumor Progression by Angiocrine FactorsElisenda Alsina-Sanchis0Ronja Mülfarth1Andreas Fischer2Division Vascular Signaling and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDivision Vascular Signaling and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDivision Vascular Signaling and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyTumor progression, therapy resistance and metastasis are profoundly controlled by the tumor microenvironment. The contribution of endothelial cells to tumor progression was initially only attributed to the formation of new blood vessels (angiogenesis). Research in the last decade has revealed however that endothelial cells control their microenvironment through the expression of membrane-bound and secreted factors. Such angiocrine functions are frequently hijacked by cancer cells, which deregulate the signaling pathways controlling the expression of angiocrine factors. Here, we review the crosstalk between cancer cells and endothelial cells and how this contributes to the cancer stem cell phenotype, epithelial to mesenchymal transition, immunosuppression, remodeling of the extracellular matrix and intravasation of cancer cells into the bloodstream. We also address the long-distance crosstalk of a primary tumor with endothelial cells at the pre-metastatic niche and how this contributes to metastasis.https://www.mdpi.com/2072-6694/13/11/2610angiocrineblood vesselsendothelial cellscancertumor progressionmetastasis |
| spellingShingle | Elisenda Alsina-Sanchis Ronja Mülfarth Andreas Fischer Control of Tumor Progression by Angiocrine Factors Cancers angiocrine blood vessels endothelial cells cancer tumor progression metastasis |
| title | Control of Tumor Progression by Angiocrine Factors |
| title_full | Control of Tumor Progression by Angiocrine Factors |
| title_fullStr | Control of Tumor Progression by Angiocrine Factors |
| title_full_unstemmed | Control of Tumor Progression by Angiocrine Factors |
| title_short | Control of Tumor Progression by Angiocrine Factors |
| title_sort | control of tumor progression by angiocrine factors |
| topic | angiocrine blood vessels endothelial cells cancer tumor progression metastasis |
| url | https://www.mdpi.com/2072-6694/13/11/2610 |
| work_keys_str_mv | AT elisendaalsinasanchis controloftumorprogressionbyangiocrinefactors AT ronjamulfarth controloftumorprogressionbyangiocrinefactors AT andreasfischer controloftumorprogressionbyangiocrinefactors |