Sensory perception of food and insulin-like signals influence seizure susceptibility.
Food deprivation is known to affect physiology and behavior. Changes that occur could be the result of the organism's monitoring of internal and external nutrient availability. In C. elegans, male mating is dependent on food availability; food-deprived males mate with lower efficiency compared...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2432499?pdf=render |
| _version_ | 1819086924699140096 |
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| author | Todd R Gruninger Daisy G Gualberto L Rene Garcia |
| author_facet | Todd R Gruninger Daisy G Gualberto L Rene Garcia |
| author_sort | Todd R Gruninger |
| collection | DOAJ |
| description | Food deprivation is known to affect physiology and behavior. Changes that occur could be the result of the organism's monitoring of internal and external nutrient availability. In C. elegans, male mating is dependent on food availability; food-deprived males mate with lower efficiency compared to their well-fed counterparts, suggesting that the mating circuit is repressed in low-food environments. This behavioral response could be mediated by sensory neurons exposed to the environment or by internal metabolic cues. We demonstrated that food-deprivation negatively regulates sex-muscle excitability through the activity of chemosensory neurons and insulin-like signaling. Specifically, we found that the repressive effects of food deprivation on the mating circuit can be partially blocked by placing males on inedible food, E. coli that can be sensed but not eaten. We determined that the olfactory AWC neurons actively suppress sex-muscle excitability in response to food deprivation. In addition, we demonstrated that loss of insulin-like receptor (DAF-2) signaling in the sex muscles blocks the ability of food deprivation to suppress the mating circuit. During low-food conditions, we propose that increased activity by specific olfactory neurons (AWCs) leads to the release of neuroendocrine signals, including insulin-like ligands. Insulin-like receptor signaling in the sex muscles then reduces cell excitability via activation of downstream molecules, including PLC-gamma and CaMKII. |
| first_indexed | 2024-12-21T21:27:59Z |
| format | Article |
| id | doaj.art-7f254e9a7c3149d0a0e2b89da504e37b |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T21:27:59Z |
| publishDate | 2008-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-7f254e9a7c3149d0a0e2b89da504e37b2022-12-21T18:49:42ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042008-07-0147e100011710.1371/journal.pgen.1000117Sensory perception of food and insulin-like signals influence seizure susceptibility.Todd R GruningerDaisy G GualbertoL Rene GarciaFood deprivation is known to affect physiology and behavior. Changes that occur could be the result of the organism's monitoring of internal and external nutrient availability. In C. elegans, male mating is dependent on food availability; food-deprived males mate with lower efficiency compared to their well-fed counterparts, suggesting that the mating circuit is repressed in low-food environments. This behavioral response could be mediated by sensory neurons exposed to the environment or by internal metabolic cues. We demonstrated that food-deprivation negatively regulates sex-muscle excitability through the activity of chemosensory neurons and insulin-like signaling. Specifically, we found that the repressive effects of food deprivation on the mating circuit can be partially blocked by placing males on inedible food, E. coli that can be sensed but not eaten. We determined that the olfactory AWC neurons actively suppress sex-muscle excitability in response to food deprivation. In addition, we demonstrated that loss of insulin-like receptor (DAF-2) signaling in the sex muscles blocks the ability of food deprivation to suppress the mating circuit. During low-food conditions, we propose that increased activity by specific olfactory neurons (AWCs) leads to the release of neuroendocrine signals, including insulin-like ligands. Insulin-like receptor signaling in the sex muscles then reduces cell excitability via activation of downstream molecules, including PLC-gamma and CaMKII.http://europepmc.org/articles/PMC2432499?pdf=render |
| spellingShingle | Todd R Gruninger Daisy G Gualberto L Rene Garcia Sensory perception of food and insulin-like signals influence seizure susceptibility. PLoS Genetics |
| title | Sensory perception of food and insulin-like signals influence seizure susceptibility. |
| title_full | Sensory perception of food and insulin-like signals influence seizure susceptibility. |
| title_fullStr | Sensory perception of food and insulin-like signals influence seizure susceptibility. |
| title_full_unstemmed | Sensory perception of food and insulin-like signals influence seizure susceptibility. |
| title_short | Sensory perception of food and insulin-like signals influence seizure susceptibility. |
| title_sort | sensory perception of food and insulin like signals influence seizure susceptibility |
| url | http://europepmc.org/articles/PMC2432499?pdf=render |
| work_keys_str_mv | AT toddrgruninger sensoryperceptionoffoodandinsulinlikesignalsinfluenceseizuresusceptibility AT daisyggualberto sensoryperceptionoffoodandinsulinlikesignalsinfluenceseizuresusceptibility AT lrenegarcia sensoryperceptionoffoodandinsulinlikesignalsinfluenceseizuresusceptibility |