Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach
<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most common chronic bacterial infection, affecting approximately half of the world’s population. <i>H. pylori</i> is a Class I carcinogen according to the World Health Organization, and the International Agency...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/18/2944 |
| _version_ | 1797580613504466944 |
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| author | Vaneet Jearth Mitali Madhumita Rath Abhirup Chatterjee Aditya Kale Manas Kumar Panigrahi |
| author_facet | Vaneet Jearth Mitali Madhumita Rath Abhirup Chatterjee Aditya Kale Manas Kumar Panigrahi |
| author_sort | Vaneet Jearth |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most common chronic bacterial infection, affecting approximately half of the world’s population. <i>H. pylori</i> is a Class I carcinogen according to the World Health Organization, and the International Agency for Research on Cancer (IARC) has linked it to 90% of stomach cancer cases worldwide. The overall pattern points to a yearly reduction in eradication rates of <i>H. pylori</i> with the likelihood of success further decreasing after each unsuccessful therapeutic effort. Antimicrobial resistance in <i>Helicobacter pylori</i> is a major public health concern and is a predominant cause attributed to eradication failure. As a result, determining <i>H. pylori</i>’s antibiotic susceptibility prior to the administration of eradication regimens becomes increasingly critical. Detecting <i>H. pylori</i> and its antimicrobial resistance has traditionally been accomplished by time-consuming culture and phenotypic drug susceptibility testing. The resistance of <i>H. pylori</i> to different antibiotics is caused by various molecular mechanisms, and advances in sequencing technology have greatly facilitated the testing of antibiotic susceptibility to <i>H. pylori</i>. This review will summarize <i>H. pylori</i> antibiotic resistance patterns, mechanisms, and clinical implications. We will also review the pros and cons of current antibiotic susceptibility testing methods. Along with a comparison of tailored susceptibility-guided regimens and empirical therapy based on the latest evidence, an evidence-based approach to such situations will be explored. |
| first_indexed | 2024-03-10T22:52:14Z |
| format | Article |
| id | doaj.art-7f26b0a35a21446686119eb91450c8b6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T22:52:14Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7f26b0a35a21446686119eb91450c8b62023-11-19T10:13:44ZengMDPI AGDiagnostics2075-44182023-09-011318294410.3390/diagnostics13182944Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based ApproachVaneet Jearth0Mitali Madhumita Rath1Abhirup Chatterjee2Aditya Kale3Manas Kumar Panigrahi4Post Graduate Institute Medical Education and Research, Chandigarh 160012, IndiaHi-Tech Medical College and Hospital, Bhubaneswar 751010, IndiaPost Graduate Institute Medical Education and Research, Chandigarh 160012, IndiaTata Memorial Hospital, Mumbai 400012, IndiaAll India Institute of Medical Sciences, Bhubaneswar 751019, India<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most common chronic bacterial infection, affecting approximately half of the world’s population. <i>H. pylori</i> is a Class I carcinogen according to the World Health Organization, and the International Agency for Research on Cancer (IARC) has linked it to 90% of stomach cancer cases worldwide. The overall pattern points to a yearly reduction in eradication rates of <i>H. pylori</i> with the likelihood of success further decreasing after each unsuccessful therapeutic effort. Antimicrobial resistance in <i>Helicobacter pylori</i> is a major public health concern and is a predominant cause attributed to eradication failure. As a result, determining <i>H. pylori</i>’s antibiotic susceptibility prior to the administration of eradication regimens becomes increasingly critical. Detecting <i>H. pylori</i> and its antimicrobial resistance has traditionally been accomplished by time-consuming culture and phenotypic drug susceptibility testing. The resistance of <i>H. pylori</i> to different antibiotics is caused by various molecular mechanisms, and advances in sequencing technology have greatly facilitated the testing of antibiotic susceptibility to <i>H. pylori</i>. This review will summarize <i>H. pylori</i> antibiotic resistance patterns, mechanisms, and clinical implications. We will also review the pros and cons of current antibiotic susceptibility testing methods. Along with a comparison of tailored susceptibility-guided regimens and empirical therapy based on the latest evidence, an evidence-based approach to such situations will be explored.https://www.mdpi.com/2075-4418/13/18/2944antibiotic resistancesingle-drug resistancemultidrug resistanceheteroresistanceantibiotic susceptibility testingtreatment failure |
| spellingShingle | Vaneet Jearth Mitali Madhumita Rath Abhirup Chatterjee Aditya Kale Manas Kumar Panigrahi Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach Diagnostics antibiotic resistance single-drug resistance multidrug resistance heteroresistance antibiotic susceptibility testing treatment failure |
| title | Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach |
| title_full | Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach |
| title_fullStr | Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach |
| title_full_unstemmed | Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach |
| title_short | Drug-Resistant <i>Helicobacter pylori</i>: Diagnosis and Evidence-Based Approach |
| title_sort | drug resistant i helicobacter pylori i diagnosis and evidence based approach |
| topic | antibiotic resistance single-drug resistance multidrug resistance heteroresistance antibiotic susceptibility testing treatment failure |
| url | https://www.mdpi.com/2075-4418/13/18/2944 |
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