MPP<sup>+</sup>-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition

MPP<sup>+</sup>-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition

The organic cation transporters OCT1-3 (<i>SLC22A1-3</i>) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug interactions (DDIs). Currently, scre...

Full description

Bibliographic Details
Main Authors: Tamara A. M. Mocking, Hubert J. Sijben, Yimé W. Vermeulen, Adriaan P. IJzerman, Laura H. Heitman
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
OCT
label-free
xCELLigence
MPP<sup>+</sup>
transport
SLC22A1-3
Online Access:https://www.mdpi.com/1422-0067/23/3/1203

Internet

https://www.mdpi.com/1422-0067/23/3/1203

Similar Items