Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of <i>APC</i> and β-Catenin Mutational Status

Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of <i>APC</i> and β-Catenin Mutational Status

Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling, which results in altered transcriptional activity of β-Catenin. Mutations in <i>APC</i> (Adenomatous Polyposis Coli) are reflected in β-Catenin hyperactivation and loss of proliferation control. Certai...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Beatrice Garavaglia, Letizia Vallino, Alessandra Ferraresi, Andrea Esposito, Amreen Salwa, Chiara Vidoni, Sergio Gentilli, Ciro Isidoro
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Biomedicines
Schlagworte:
short chain fatty acid (SCFA)
cell proliferation
WNT signaling pathway
microbiota
autophagy
LC3
Online Zugang:https://www.mdpi.com/2227-9059/10/5/1131

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