Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5
Recent studies have revealed the feasibility of sodium acetate as a potentially novel inhibitor/stressor relevant to the fermentation from neutralized lignocellulosic hydrolysates. This mini-review focuses on the toxicity of sodium acetate, which is composed of both sodium and acetate ions, and on t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02495/full |
| _version_ | 1811317890669871104 |
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| author | Akaraphol Watcharawipas Daisuke Watanabe Hiroshi Takagi |
| author_facet | Akaraphol Watcharawipas Daisuke Watanabe Hiroshi Takagi |
| author_sort | Akaraphol Watcharawipas |
| collection | DOAJ |
| description | Recent studies have revealed the feasibility of sodium acetate as a potentially novel inhibitor/stressor relevant to the fermentation from neutralized lignocellulosic hydrolysates. This mini-review focuses on the toxicity of sodium acetate, which is composed of both sodium and acetate ions, and on the involved cellular responses that it elicits, particularly via the high-osmolarity glycerol (HOG) pathway, the Rim101 pathway, the P-type ATPase sodium pumps Ena1/2/5, and the ubiquitin ligase Rsp5 with its adaptors. Increased understanding of cellular responses to sodium acetate would improve our understanding of how cells respond not only to different stimuli but also to composite stresses induced by multiple components (e.g., sodium and acetate) simultaneously. Moreover, unraveling the characteristics of specific stresses under industrially related conditions and the cellular responses evoked by these stresses would be a key factor in the industrial yeast strain engineering toward the increased productivity of not only bioethanol but also advanced biofuels and valuable chemicals that will be in demand in the coming era of bio-based industry. |
| first_indexed | 2024-04-13T12:16:15Z |
| format | Article |
| id | doaj.art-7f2a2cc129364958b468301653ce63d8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T12:16:15Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7f2a2cc129364958b468301653ce63d82022-12-22T02:47:21ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-10-01910.3389/fmicb.2018.02495415158Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5Akaraphol WatcharawipasDaisuke WatanabeHiroshi TakagiRecent studies have revealed the feasibility of sodium acetate as a potentially novel inhibitor/stressor relevant to the fermentation from neutralized lignocellulosic hydrolysates. This mini-review focuses on the toxicity of sodium acetate, which is composed of both sodium and acetate ions, and on the involved cellular responses that it elicits, particularly via the high-osmolarity glycerol (HOG) pathway, the Rim101 pathway, the P-type ATPase sodium pumps Ena1/2/5, and the ubiquitin ligase Rsp5 with its adaptors. Increased understanding of cellular responses to sodium acetate would improve our understanding of how cells respond not only to different stimuli but also to composite stresses induced by multiple components (e.g., sodium and acetate) simultaneously. Moreover, unraveling the characteristics of specific stresses under industrially related conditions and the cellular responses evoked by these stresses would be a key factor in the industrial yeast strain engineering toward the increased productivity of not only bioethanol but also advanced biofuels and valuable chemicals that will be in demand in the coming era of bio-based industry.https://www.frontiersin.org/article/10.3389/fmicb.2018.02495/fullSaccharomyces cerevisiaeubiquitin ligaseRsp5sodium acetate responsesP-type ATPase sodium pumpsEna1/2/5 |
| spellingShingle | Akaraphol Watcharawipas Daisuke Watanabe Hiroshi Takagi Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 Frontiers in Microbiology Saccharomyces cerevisiae ubiquitin ligase Rsp5 sodium acetate responses P-type ATPase sodium pumps Ena1/2/5 |
| title | Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 |
| title_full | Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 |
| title_fullStr | Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 |
| title_full_unstemmed | Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 |
| title_short | Sodium Acetate Responses in Saccharomyces cerevisiae and the Ubiquitin Ligase Rsp5 |
| title_sort | sodium acetate responses in saccharomyces cerevisiae and the ubiquitin ligase rsp5 |
| topic | Saccharomyces cerevisiae ubiquitin ligase Rsp5 sodium acetate responses P-type ATPase sodium pumps Ena1/2/5 |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.02495/full |
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