Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or lo...

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Bibliographic Details
Main Authors: Kiran Mahajan, Domenico Coppola, Sridevi Challa, Bin Fang, Y Ann Chen, Weiwei Zhu, Alexis S Lopez, John Koomen, Robert W Engelman, Charlene Rivera, Rebecca S Muraoka-Cook, Jin Q Cheng, Ernst Schönbrunn, Said M Sebti, H Shelton Earp, Nupam P Mahajan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2841635?pdf=render

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