Mouse models of follicular and papillary thyroid cancer progression
A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00119/full |
| _version_ | 1818929729028227072 |
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| author | Marika A. Russo Valeria G. Antico Arciuch Antonio eDi Cristofano |
| author_facet | Marika A. Russo Valeria G. Antico Arciuch Antonio eDi Cristofano |
| author_sort | Marika A. Russo |
| collection | DOAJ |
| description | A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets.In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas. |
| first_indexed | 2024-12-20T03:49:25Z |
| format | Article |
| id | doaj.art-7f2e082937ac4a038c7039c9ed5b3c9e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T03:49:25Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7f2e082937ac4a038c7039c9ed5b3c9e2022-12-21T19:54:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922012-01-01210.3389/fendo.2011.0011919919Mouse models of follicular and papillary thyroid cancer progressionMarika A. Russo0Valeria G. Antico Arciuch1Antonio eDi Cristofano2Albert Einstein College of MedicineAlbert Einstein College of MedicineAlbert Einstein College of MedicineA significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets.In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas.http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00119/fullCancerMousethyroidprogression |
| spellingShingle | Marika A. Russo Valeria G. Antico Arciuch Antonio eDi Cristofano Mouse models of follicular and papillary thyroid cancer progression Frontiers in Endocrinology Cancer Mouse thyroid progression |
| title | Mouse models of follicular and papillary thyroid cancer progression |
| title_full | Mouse models of follicular and papillary thyroid cancer progression |
| title_fullStr | Mouse models of follicular and papillary thyroid cancer progression |
| title_full_unstemmed | Mouse models of follicular and papillary thyroid cancer progression |
| title_short | Mouse models of follicular and papillary thyroid cancer progression |
| title_sort | mouse models of follicular and papillary thyroid cancer progression |
| topic | Cancer Mouse thyroid progression |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00119/full |
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