Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome
Sweet's syndrome and eosinophilic folliculitis are aseptic inflammatory dermatitis mainly because of infiltrated neutrophils and eosinophils on skin, respectively. These diseases rarely overlap or coexist in the same patient, especially co-occur in HIV infected patient. Here, we report a rare c...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00343/full |
| _version_ | 1818513099722850304 |
|---|---|
| author | Rong-Jing Dong Shi-Zhen Huang Pratishtha Upadhyay Samip Shrestha Ya-Jie Zhai Yu-Ye Li |
| author_facet | Rong-Jing Dong Shi-Zhen Huang Pratishtha Upadhyay Samip Shrestha Ya-Jie Zhai Yu-Ye Li |
| author_sort | Rong-Jing Dong |
| collection | DOAJ |
| description | Sweet's syndrome and eosinophilic folliculitis are aseptic inflammatory dermatitis mainly because of infiltrated neutrophils and eosinophils on skin, respectively. These diseases rarely overlap or coexist in the same patient, especially co-occur in HIV infected patient. Here, we report a rare case of an AIDS patient who developed eosinophilic folliculitis and Sweet's syndrome within 1 month of initial antiretroviral therapy, presumably due to immune reconstitution inflammatory syndrome. The CD4+ T cell counts increased dramatically from 70 to 249 cells/μL within a period of 1 month. Interestingly, the patient was rapidly and strikingly responsive to thalidomide, which has anti-inflammatory, immune regulation, inhibition of neutrophil chemotaxis etc. Moreover, we focused our attention on discussing the clinical, pathological, and possible pathogenic aspects of the rare overlap of HIV complicated with neutrophilic and eosinophilic dermatosis. |
| first_indexed | 2024-12-10T23:56:18Z |
| format | Article |
| id | doaj.art-7f2e3aaca1e746bbb61b3c247906f8af |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T23:56:18Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7f2e3aaca1e746bbb61b3c247906f8af2022-12-22T01:28:35ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-01-01610.3389/fmed.2019.00343498949Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory SyndromeRong-Jing Dong0Shi-Zhen Huang1Pratishtha Upadhyay2Samip Shrestha3Ya-Jie Zhai4Yu-Ye Li5Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center (YNACC), Anning, ChinaDepartment of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Dermatology and Venereology, Jining Second People's Hospital, Jining, ChinaDepartment of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaSweet's syndrome and eosinophilic folliculitis are aseptic inflammatory dermatitis mainly because of infiltrated neutrophils and eosinophils on skin, respectively. These diseases rarely overlap or coexist in the same patient, especially co-occur in HIV infected patient. Here, we report a rare case of an AIDS patient who developed eosinophilic folliculitis and Sweet's syndrome within 1 month of initial antiretroviral therapy, presumably due to immune reconstitution inflammatory syndrome. The CD4+ T cell counts increased dramatically from 70 to 249 cells/μL within a period of 1 month. Interestingly, the patient was rapidly and strikingly responsive to thalidomide, which has anti-inflammatory, immune regulation, inhibition of neutrophil chemotaxis etc. Moreover, we focused our attention on discussing the clinical, pathological, and possible pathogenic aspects of the rare overlap of HIV complicated with neutrophilic and eosinophilic dermatosis.https://www.frontiersin.org/article/10.3389/fmed.2019.00343/fullAIDSthalidomidesweet's syndromeeosinophilic folliculitisIRIS |
| spellingShingle | Rong-Jing Dong Shi-Zhen Huang Pratishtha Upadhyay Samip Shrestha Ya-Jie Zhai Yu-Ye Li Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome Frontiers in Medicine AIDS thalidomide sweet's syndrome eosinophilic folliculitis IRIS |
| title | Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome |
| title_full | Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome |
| title_fullStr | Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome |
| title_full_unstemmed | Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome |
| title_short | Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome |
| title_sort | thalidomide in the treatment of sweet s syndrome and eosinophilic folliculitis associated with immune reconstitution inflammatory syndrome |
| topic | AIDS thalidomide sweet's syndrome eosinophilic folliculitis IRIS |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00343/full |
| work_keys_str_mv | AT rongjingdong thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome AT shizhenhuang thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome AT pratishthaupadhyay thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome AT samipshrestha thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome AT yajiezhai thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome AT yuyeli thalidomideinthetreatmentofsweetssyndromeandeosinophilicfolliculitisassociatedwithimmunereconstitutioninflammatorysyndrome |