SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

Abstract Background Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP remains a complicated issue for pain management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2) are members of the SPOCK family that play a significant role in the d...

Full description

Bibliographic Details
Main Authors: Chenglong Wang, Yitong Xu, Miao Xu, Cong Sun, Xiaojiao Zhang, Xueshu Tao, Tao Song
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Neuroinflammation
Subjects:
SPOCK2
Neuropathic pain
Astrocyte
CCI
MMP-2
MT1-MMP
Online Access:https://doi.org/10.1186/s12974-024-03051-5

Similar Items

Similar Items