NU7441 Enhances the Radiosensitivity of Liver Cancer Cells

NU7441 Enhances the Radiosensitivity of Liver Cancer Cells

Objective: Radiation therapy, one of the major treatments for liver cancer, causes DNA damage and cell death. Since the liver cancer cells have a strong capacity to repair irradiative injury, new medicines to enhance this treatment are urgently required. In this study, we investigated the effect of...

Full description

Bibliographic Details
Main Authors:	Chuanjie Yang, Quanxu Wang, Xiaodan Liu, Xiulian Cheng, Xiaoyu Jiang, Yuan Zhang, Zhijie Feng, Pingkun Zhou
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Series:	Cellular Physiology and Biochemistry
Subjects:	NU7441 Hepatocellular carcinoma Radiosensitization Non-homologous end joining DNA-PK
Online Access:	http://www.karger.com/Article/FullText/445551

Similar Items

Transcriptomic data of BT549 triple negative breast cancer cells treated with 20 µM NU7441, a DNA-dependent kinase inhibitor
by: Kunyan Li, et al.
Published: (2024-04-01)

NU7441, a selective inhibitor of DNA-PKcs, alleviates intracerebral hemorrhage injury with suppression of ferroptosis in brain
by: Xiyu Gong, et al.
Published: (2024-11-01)

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer
by: Guangchao Wang, et al.
Published: (2020-10-01)

Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
by: Jiawen Han, et al.
Published: (2023-03-01)

Radiosensitizing activity of novel small molecule BRCA1 and DNA-PK inhibitors in lung and colon carcinoma
by: Suraj Radhamani, Ph.D, et al.
Published: (2017-07-01)

Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth
by: Ling Zeng, et al.
Published: (2020-09-01)

Artemis and its role in cancer
by: Armen Parsyan, et al.
Published: (2025-01-01)

Radio-Sensitization of Human Leukaemic MOLT-4 Cells by DNA-Dependent Protein Kinase Inhibitor, NU7026
by: Aleš Tichý, et al.
Published: (2012-01-01)

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs
by: Muddenahalli Srinivasa Sudhanva, et al.
Published: (2022-04-01)

Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity
by: Juan C. Alamilla-Presuel
Published: (2023-09-01)

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
by: Alexandra C. Vítor, et al.
Published: (2020-02-01)

Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches
by: Erika Nakatsuka, et al.
Published: (2024-12-01)

Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles
by: Natasha D. Ratnayaka-Gamage, et al.
Published: (2023-10-01)

Hepatitis B Virus DNA Integration: In Vitro Models for Investigating Viral Pathogenesis and Persistence
by: Thomas Tu, et al.
Published: (2021-01-01)

Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination
by: Sugith Badugu, et al.
Published: (2024-12-01)

Research progress on HPV-positive oropharyngeal carcinoma sensitive to radiation therapy
by: CHEN Yongju, et al.
Published: (2021-01-01)

MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
by: Xucui Zhuang, et al.
Published: (2023-09-01)

Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
by: Xin Zhang, et al.
Published: (2017-09-01)

Functional Roles of Homologous Recombination and Non-Homologous End Joining in DNA Damage Response and Microevolution in <i>Cryptococcus neoformans</i>
by: Kwang-Woo Jung, et al.
Published: (2021-07-01)

To Join or Not to Join: Decision Points Along the Pathway to Double-Strand Break Repair vs. Chromosome End Protection
by: Stephanie M. Ackerson, et al.
Published: (2021-07-01)

A novel NHEJ gene signature based model for risk stratification and prognosis prediction in hepatocellular carcinoma
by: Zhu Lin, et al.
Published: (2023-04-01)

The role and clinical significance of DNA damage response and repair pathways in primary brain tumors
by: Santivasi Wil L, et al.
Published: (2013-02-01)

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing
by: Mathilde Meyenberg, et al.
Published: (2021-09-01)

Molecular Process Producing Oncogene Fusion in Lung Cancer Cells by Illegitimate Repair of DNA Double-Strand Breaks
by: Yoshitaka Seki, et al.
Published: (2015-09-01)

BVAN08 enhances radiosensitivity via downregulation of DNA-PKcs towards hepatic tumor xenograft
by: Bo Zhang, et al.
Published: (2020-09-01)

Negative feedback loop in the activation of non-homologous end joining DNA repair pathway in Helicobacter pylori infected patients with gastritis
by: Mohsen Amirnorouzi, et al.
Published: (2024-10-01)

Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction
by: RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang
Published: (2022-04-01)

Non-Homologous End-Joining Pathway Genotypes Significantly Associated with Nasopharyngeal Carcinoma Susceptibility
by: Chia-Wen Tsai, et al.
Published: (2023-06-01)

The role of DNA double-strand break repair defects in the pathogenesis of neurodegenerative diseases
by: Jie Xinyu, et al.
Published: (2023-06-01)

Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation
by: Monica Pandey, et al.
Published: (2019-01-01)

Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells
by: Sarah Degenhardt, et al.
Published: (2020-08-01)

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
by: Kirsi J. Rautajoki, et al.
Published: (2023-11-01)

Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair
by: Zhen Qian, et al.
Published: (2023-12-01)

The regulation of DNA end resection by chromatin response to DNA double strand breaks
by: Bo-Ruei Chen, et al.
Published: (2022-07-01)

Non-homologous DNA end joining in normal and cancer cells and its dependence on break structures
by: Tomasz Poplawski, et al.
Published: (2010-01-01)

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
by: Zhiqiang Wu, et al.
Published: (2019-04-01)

Multiple and variable NHEJ-like genes are involved in resistance to DNA damage in Streptomyces ambofaciens
by: Grégory Hoff, et al.
Published: (2016-11-01)

HBV DNA Integration: Molecular Mechanisms and Clinical Implications
by: Thomas Tu, et al.
Published: (2017-04-01)

Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery
by: Kaitao Zhao, et al.
Published: (2020-08-01)

BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair
by: Yangyang Kong, et al.
Published: (2022-08-01)