Toll-like receptor 4 (TLR4): new insight immune and aging
Abstract TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12979-023-00383-3 |
| _version_ | 1797451483433664512 |
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| author | Hyo-Jin Kim Hyemin Kim Jeong-Hyung Lee Cheol Hwangbo |
| author_facet | Hyo-Jin Kim Hyemin Kim Jeong-Hyung Lee Cheol Hwangbo |
| author_sort | Hyo-Jin Kim |
| collection | DOAJ |
| description | Abstract TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory cytokines. Another adapter protein linked to TLR4, known as TRIF, autonomously propagates signaling pathways, resulting in heightened interferon expression. Recently, TLR4 has garnered attention as a significant factor in the regulation of symptoms in aging-related disorders. The persistent inflammatory response triggered by TLR4 contributes to the onset and exacerbation of these disorders. In addition, alterations in TLR4 expression levels play a pivotal role in modifying the manifestations of age-related diseases. In this review, we aim to consolidate the impact of TLR4 on cellular senescence and aging-related ailments, highlighting the potential of TLR4 as a novel therapeutic target that extends beyond immune responses. |
| first_indexed | 2024-03-09T14:55:19Z |
| format | Article |
| id | doaj.art-7f318e570edd460dbc1c411fd9971cbb |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-03-09T14:55:19Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-7f318e570edd460dbc1c411fd9971cbb2023-11-26T14:13:59ZengBMCImmunity & Ageing1742-49332023-11-0120111110.1186/s12979-023-00383-3Toll-like receptor 4 (TLR4): new insight immune and agingHyo-Jin Kim0Hyemin Kim1Jeong-Hyung Lee2Cheol Hwangbo3Division of Life Science, College of Natural Sciences, Gyeongsang National UniversityDivision of Applied Life Science (BK21 Four), Research Institute of Life Sciences, Gyeongsang National UniversityDepartment of Biochemistry (BK21 Four), College of Natural Sciences, Kangwon National UniversityDivision of Life Science, College of Natural Sciences, Gyeongsang National UniversityAbstract TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory cytokines. Another adapter protein linked to TLR4, known as TRIF, autonomously propagates signaling pathways, resulting in heightened interferon expression. Recently, TLR4 has garnered attention as a significant factor in the regulation of symptoms in aging-related disorders. The persistent inflammatory response triggered by TLR4 contributes to the onset and exacerbation of these disorders. In addition, alterations in TLR4 expression levels play a pivotal role in modifying the manifestations of age-related diseases. In this review, we aim to consolidate the impact of TLR4 on cellular senescence and aging-related ailments, highlighting the potential of TLR4 as a novel therapeutic target that extends beyond immune responses.https://doi.org/10.1186/s12979-023-00383-3TLR4Age-related diseaseCellular senescenceAging |
| spellingShingle | Hyo-Jin Kim Hyemin Kim Jeong-Hyung Lee Cheol Hwangbo Toll-like receptor 4 (TLR4): new insight immune and aging Immunity & Ageing TLR4 Age-related disease Cellular senescence Aging |
| title | Toll-like receptor 4 (TLR4): new insight immune and aging |
| title_full | Toll-like receptor 4 (TLR4): new insight immune and aging |
| title_fullStr | Toll-like receptor 4 (TLR4): new insight immune and aging |
| title_full_unstemmed | Toll-like receptor 4 (TLR4): new insight immune and aging |
| title_short | Toll-like receptor 4 (TLR4): new insight immune and aging |
| title_sort | toll like receptor 4 tlr4 new insight immune and aging |
| topic | TLR4 Age-related disease Cellular senescence Aging |
| url | https://doi.org/10.1186/s12979-023-00383-3 |
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