Systemic Mastocytosis Imitating Eosinophilic Enterocolitis
Eosinophilic gastrointestinal disorders produce gastrointestinal dysfunction as eosinophils accumulate throughout gastrointestinal tissues. The majority of eosinophilic gastrointestinal disorders are a diagnosis of exclusion, and a magnitude of differentials must be considered. A history of anaphyla...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572322000164 |
| _version_ | 1811257813673967616 |
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| author | Tamlynn Lynette Muller Kevin Van Der Merwe Chris Steele Maria Papanikolaou Gerry O'Dowd Vikrant Parihar |
| author_facet | Tamlynn Lynette Muller Kevin Van Der Merwe Chris Steele Maria Papanikolaou Gerry O'Dowd Vikrant Parihar |
| author_sort | Tamlynn Lynette Muller |
| collection | DOAJ |
| description | Eosinophilic gastrointestinal disorders produce gastrointestinal dysfunction as eosinophils accumulate throughout gastrointestinal tissues. The majority of eosinophilic gastrointestinal disorders are a diagnosis of exclusion, and a magnitude of differentials must be considered. A history of anaphylaxis raises the suspicion that systemic mastocytosis (SM) is the foremost differential to be considered. SM (hematological neoplasm) is characterized by the accumulation of clonal mast cells in systemic tissues that causes gastrointestinal manifestations. In these rare cases, serum tryptase and tissue staining for c-kit/CD117 (an immunohistochemical marker of mast cells) will clinch the diagnosis. Gastrointestinal manifestations of SM are expeditiously resolved with combined oral antihistamines. |
| first_indexed | 2024-04-12T18:04:27Z |
| format | Article |
| id | doaj.art-7f32862af5184f6eaf4602d17d7c2d5b |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-04-12T18:04:27Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-7f32862af5184f6eaf4602d17d7c2d5b2022-12-22T03:22:03ZengElsevierGastro Hep Advances2772-57232022-01-0113417419Systemic Mastocytosis Imitating Eosinophilic EnterocolitisTamlynn Lynette Muller0Kevin Van Der Merwe1Chris Steele2Maria Papanikolaou3Gerry O'Dowd4Vikrant Parihar5Department of Internal Medicine, Letterkenny University Hospital, Letterkenny Co. Donegal, IrelandDepartment of Internal Medicine, Letterkenny University Hospital, Letterkenny Co. Donegal, IrelandDepartment of Gastroenterology, Letterkenny University Hospital, Letterkenny Co. Donegal, IrelandDepartment of Haematology, Letterkenny University Hospital, Letterkenny Co. Donegal, IrelandDepartment of Histopathology, Letterkenny University Hospital, Letterkenny Co. Donegal, IrelandDepartment of Gastroenterology, Letterkenny University Hospital, Letterkenny Co. Donegal, Ireland; Correspondence: Address correspondence to: Dr Vikrant Parihar, MD, Consultant Gastroenterologist, Department of Gastroenterology, Letterkenny University Hospital, Ireland.Eosinophilic gastrointestinal disorders produce gastrointestinal dysfunction as eosinophils accumulate throughout gastrointestinal tissues. The majority of eosinophilic gastrointestinal disorders are a diagnosis of exclusion, and a magnitude of differentials must be considered. A history of anaphylaxis raises the suspicion that systemic mastocytosis (SM) is the foremost differential to be considered. SM (hematological neoplasm) is characterized by the accumulation of clonal mast cells in systemic tissues that causes gastrointestinal manifestations. In these rare cases, serum tryptase and tissue staining for c-kit/CD117 (an immunohistochemical marker of mast cells) will clinch the diagnosis. Gastrointestinal manifestations of SM are expeditiously resolved with combined oral antihistamines.http://www.sciencedirect.com/science/article/pii/S2772572322000164Allergies, Colonoscopy, Diarrhoea, Mast Cells, Skin Manifestations |
| spellingShingle | Tamlynn Lynette Muller Kevin Van Der Merwe Chris Steele Maria Papanikolaou Gerry O'Dowd Vikrant Parihar Systemic Mastocytosis Imitating Eosinophilic Enterocolitis Gastro Hep Advances Allergies, Colonoscopy, Diarrhoea, Mast Cells, Skin Manifestations |
| title | Systemic Mastocytosis Imitating Eosinophilic Enterocolitis |
| title_full | Systemic Mastocytosis Imitating Eosinophilic Enterocolitis |
| title_fullStr | Systemic Mastocytosis Imitating Eosinophilic Enterocolitis |
| title_full_unstemmed | Systemic Mastocytosis Imitating Eosinophilic Enterocolitis |
| title_short | Systemic Mastocytosis Imitating Eosinophilic Enterocolitis |
| title_sort | systemic mastocytosis imitating eosinophilic enterocolitis |
| topic | Allergies, Colonoscopy, Diarrhoea, Mast Cells, Skin Manifestations |
| url | http://www.sciencedirect.com/science/article/pii/S2772572322000164 |
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