(R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate
The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C—C—C—O torsion angle is −16.35 (17) °] and the piperidinyl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Union of Crystallography
2011-10-01
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| Series: | Acta Crystallographica Section E |
| Online Access: | http://scripts.iucr.org/cgi-bin/paper?S1600536811038128 |
| _version_ | 1798031549906550784 |
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| author | Edward R. T. Tiekink Solange M. S. V. Wardell James L. Wardell Marcus V. N. de Souza Raoni S. B. Gonçalves |
| author_facet | Edward R. T. Tiekink Solange M. S. V. Wardell James L. Wardell Marcus V. N. de Souza Raoni S. B. Gonçalves |
| author_sort | Edward R. T. Tiekink |
| collection | DOAJ |
| description | The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C—C—C—O torsion angle is −16.35 (17) °] and the piperidinyl group [distorted chair conformation] lies to one side of the quinolinyl ring system. The hydroxyl and carbonyl groups lie to either side of the molecule, enabling their participation in intermolecular interactions. Thus, the hydroxyl and carbonyl groups of two centrosymmetrically related molecules are bridged by two methanol molecules via O—H...O hydrogen bonds, leading to a four-molecule aggregate. These are linked into a supramolecular chain along the a axis via C—H...O interactions involving the hydroxyl-O atom. The chains assemble into layers that interdigitate along the c axis being connected by C—H...F interactions. |
| first_indexed | 2024-04-11T19:59:06Z |
| format | Article |
| id | doaj.art-7f32bc5935954c1d91558565e99765b2 |
| institution | Directory Open Access Journal |
| issn | 1600-5368 |
| language | English |
| last_indexed | 2024-04-11T19:59:06Z |
| publishDate | 2011-10-01 |
| publisher | International Union of Crystallography |
| record_format | Article |
| series | Acta Crystallographica Section E |
| spelling | doaj.art-7f32bc5935954c1d91558565e99765b22022-12-22T04:05:43ZengInternational Union of CrystallographyActa Crystallographica Section E1600-53682011-10-016710o2714o271510.1107/S1600536811038128(R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvateEdward R. T. TiekinkSolange M. S. V. WardellJames L. WardellMarcus V. N. de SouzaRaoni S. B. GonçalvesThe title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C—C—C—O torsion angle is −16.35 (17) °] and the piperidinyl group [distorted chair conformation] lies to one side of the quinolinyl ring system. The hydroxyl and carbonyl groups lie to either side of the molecule, enabling their participation in intermolecular interactions. Thus, the hydroxyl and carbonyl groups of two centrosymmetrically related molecules are bridged by two methanol molecules via O—H...O hydrogen bonds, leading to a four-molecule aggregate. These are linked into a supramolecular chain along the a axis via C—H...O interactions involving the hydroxyl-O atom. The chains assemble into layers that interdigitate along the c axis being connected by C—H...F interactions.http://scripts.iucr.org/cgi-bin/paper?S1600536811038128 |
| spellingShingle | Edward R. T. Tiekink Solange M. S. V. Wardell James L. Wardell Marcus V. N. de Souza Raoni S. B. Gonçalves (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate Acta Crystallographica Section E |
| title | (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate |
| title_full | (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate |
| title_fullStr | (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate |
| title_full_unstemmed | (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate |
| title_short | (R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate |
| title_sort | r s amp 177 1 2 2 8 bis trifluoromethyl quinolin 4 yl hydroxy methyl piperidin 1 yl ethanone methanol monosolvate |
| url | http://scripts.iucr.org/cgi-bin/paper?S1600536811038128 |
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