Piperine: Chemistry and Biology
Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (<i>Piper nigrum</i> L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological activities, including not only medi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/15/12/696 |
| _version_ | 1827573431487430656 |
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| author | Jin Han Shaoyong Zhang Jun He Tianze Li |
| author_facet | Jin Han Shaoyong Zhang Jun He Tianze Li |
| author_sort | Jin Han |
| collection | DOAJ |
| description | Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (<i>Piper nigrum</i> L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological activities, including not only medical but also agricultural bioactivities. In order to achieve sustainable development and improve survival conditions, looking for environmentally friendly pesticides with low toxicity and residue is an extremely urgent challenge. Fortunately, plant-derived pesticides are rising like a shining star, guiding us in the direction of development in pesticidal research. In the present review, the recent progress in the biological activities, mechanisms of action, and structural modifications of piperine and its derivatives from 2020 to 2023 are summarized. The structure-activity relationships were analyzed in order to pave the way for future development and utilization of piperine and its derivatives as potent drugs and pesticides for improving the local economic development. |
| first_indexed | 2024-03-08T20:19:13Z |
| format | Article |
| id | doaj.art-7f379e3019c24c22a88ef81e1666e477 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-08T20:19:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-7f379e3019c24c22a88ef81e1666e4772023-12-22T14:46:18ZengMDPI AGToxins2072-66512023-12-01151269610.3390/toxins15120696Piperine: Chemistry and BiologyJin Han0Shaoyong Zhang1Jun He2Tianze Li3School of Public Administration, Xi’an University of Finance and Economics, Xi’an 710061, ChinaKey Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, ChinaCollege of Plant Protection, Northwest A&F University, Xianyang 712100, ChinaCollege of Plant Protection, Northwest A&F University, Xianyang 712100, ChinaPiperine is a plant-derived promising piperamide candidate isolated from the black pepper (<i>Piper nigrum</i> L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological activities, including not only medical but also agricultural bioactivities. In order to achieve sustainable development and improve survival conditions, looking for environmentally friendly pesticides with low toxicity and residue is an extremely urgent challenge. Fortunately, plant-derived pesticides are rising like a shining star, guiding us in the direction of development in pesticidal research. In the present review, the recent progress in the biological activities, mechanisms of action, and structural modifications of piperine and its derivatives from 2020 to 2023 are summarized. The structure-activity relationships were analyzed in order to pave the way for future development and utilization of piperine and its derivatives as potent drugs and pesticides for improving the local economic development.https://www.mdpi.com/2072-6651/15/12/696piperinepiperine derivativesbiological activitymechanism of actionstructural modificationstructure-activity relationship |
| spellingShingle | Jin Han Shaoyong Zhang Jun He Tianze Li Piperine: Chemistry and Biology Toxins piperine piperine derivatives biological activity mechanism of action structural modification structure-activity relationship |
| title | Piperine: Chemistry and Biology |
| title_full | Piperine: Chemistry and Biology |
| title_fullStr | Piperine: Chemistry and Biology |
| title_full_unstemmed | Piperine: Chemistry and Biology |
| title_short | Piperine: Chemistry and Biology |
| title_sort | piperine chemistry and biology |
| topic | piperine piperine derivatives biological activity mechanism of action structural modification structure-activity relationship |
| url | https://www.mdpi.com/2072-6651/15/12/696 |
| work_keys_str_mv | AT jinhan piperinechemistryandbiology AT shaoyongzhang piperinechemistryandbiology AT junhe piperinechemistryandbiology AT tianzeli piperinechemistryandbiology |