Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours
Purpose: (i) to compare two 2.45 GHz MWA devices with respect to AZV in relation to the applied energy after MWA in patients with hepatocellular carcinoma (HCC) or colorectal liver metastasis (CRLM) and (ii) to identify potential confounders for this relationship. Methods: In total, 102 tumours, 65...
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/22/5570 |
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| author | Simeon J. S. Ruiter Jamila E. de Jong Jan Pieter Pennings Robbert J. de Haas Koert P. de Jong |
| author_facet | Simeon J. S. Ruiter Jamila E. de Jong Jan Pieter Pennings Robbert J. de Haas Koert P. de Jong |
| author_sort | Simeon J. S. Ruiter |
| collection | DOAJ |
| description | Purpose: (i) to compare two 2.45 GHz MWA devices with respect to AZV in relation to the applied energy after MWA in patients with hepatocellular carcinoma (HCC) or colorectal liver metastasis (CRLM) and (ii) to identify potential confounders for this relationship. Methods: In total, 102 tumours, 65 CRLM and 37 HCC were included in this retrospective analysis. Tumours were treated with Emprint (<i>n</i> = 71) or Neuwave (<i>n</i> = 31) MWA devices. Ablation treatment setting were recorded and applied energy was calculated. AZV and tumour volumes were segmented on the contrast-enhanced CT scans obtained 1 week after treatment. The AZV to applied energy <i>R</i>(AZV:E) ratios were calculated for each tumour treatment and compared between both MWA devices and tumour types. Results: <i>R</i>(AZV:E)<sub>EMPRINT</sub> was 0.41 and <i>R</i>(AZV:E)<sub>NEUWAVE</sub> was 0.81, <i>p</i> < 0.001. Moderate correlation between AZV and applied energy was found for Emprint (r = 0.57, <i>R</i><sup>2</sup> = 0.32, <i>p</i> < 0.001) and strong correlation was found for Neuwave (r = 0.78, <i>R</i><sup>2</sup> = 0.61, <i>p</i> < 0.001). <i>R</i>(AZV:E)<sub>CRLM</sub> was 0.45 and <i>R</i>(AZV:E)<sub>HCC</sub> was 0.52, <i>p</i> = 0.270. Conclusion: This study confirms the unpredictability of AZVs based on the applied output energy for HCC and CRLM. No significant differences in <i>R</i>(AZV:E) were observed between CRLM and HCC. Significantly lower <i>R</i>(AZV:E) was found for Emprint devices compared to Neuwave; however, reflected energy due to cable and antenna design remains unclear and might contribute to these differences. |
| first_indexed | 2024-03-09T18:26:29Z |
| format | Article |
| id | doaj.art-7f37a4a59a6640ba8db59a30958e7fd7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7f37a4a59a6640ba8db59a30958e7fd72023-11-24T07:53:18ZengMDPI AGCancers2072-66942022-11-011422557010.3390/cancers14225570Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver TumoursSimeon J. S. Ruiter0Jamila E. de Jong1Jan Pieter Pennings2Robbert J. de Haas3Koert P. de Jong4Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsPurpose: (i) to compare two 2.45 GHz MWA devices with respect to AZV in relation to the applied energy after MWA in patients with hepatocellular carcinoma (HCC) or colorectal liver metastasis (CRLM) and (ii) to identify potential confounders for this relationship. Methods: In total, 102 tumours, 65 CRLM and 37 HCC were included in this retrospective analysis. Tumours were treated with Emprint (<i>n</i> = 71) or Neuwave (<i>n</i> = 31) MWA devices. Ablation treatment setting were recorded and applied energy was calculated. AZV and tumour volumes were segmented on the contrast-enhanced CT scans obtained 1 week after treatment. The AZV to applied energy <i>R</i>(AZV:E) ratios were calculated for each tumour treatment and compared between both MWA devices and tumour types. Results: <i>R</i>(AZV:E)<sub>EMPRINT</sub> was 0.41 and <i>R</i>(AZV:E)<sub>NEUWAVE</sub> was 0.81, <i>p</i> < 0.001. Moderate correlation between AZV and applied energy was found for Emprint (r = 0.57, <i>R</i><sup>2</sup> = 0.32, <i>p</i> < 0.001) and strong correlation was found for Neuwave (r = 0.78, <i>R</i><sup>2</sup> = 0.61, <i>p</i> < 0.001). <i>R</i>(AZV:E)<sub>CRLM</sub> was 0.45 and <i>R</i>(AZV:E)<sub>HCC</sub> was 0.52, <i>p</i> = 0.270. Conclusion: This study confirms the unpredictability of AZVs based on the applied output energy for HCC and CRLM. No significant differences in <i>R</i>(AZV:E) were observed between CRLM and HCC. Significantly lower <i>R</i>(AZV:E) was found for Emprint devices compared to Neuwave; however, reflected energy due to cable and antenna design remains unclear and might contribute to these differences.https://www.mdpi.com/2072-6694/14/22/5570colorectal liver metastasishepatocellular carcinomathermal ablationmicrowave ablation |
| spellingShingle | Simeon J. S. Ruiter Jamila E. de Jong Jan Pieter Pennings Robbert J. de Haas Koert P. de Jong Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours Cancers colorectal liver metastasis hepatocellular carcinoma thermal ablation microwave ablation |
| title | Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours |
| title_full | Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours |
| title_fullStr | Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours |
| title_full_unstemmed | Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours |
| title_short | Comparison of Two 2.45 GHz Microwave Ablation Devices with Respect to Ablation Zone Volume in Relation to Applied Energy in Patients with Malignant Liver Tumours |
| title_sort | comparison of two 2 45 ghz microwave ablation devices with respect to ablation zone volume in relation to applied energy in patients with malignant liver tumours |
| topic | colorectal liver metastasis hepatocellular carcinoma thermal ablation microwave ablation |
| url | https://www.mdpi.com/2072-6694/14/22/5570 |
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