Effect of Antioxidant on Sperm Freezing
A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress. Aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions, such as sperm capacitation and acrosome reactions require moderate levels of ROS....
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| Format: | Article |
| Language: | fas |
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Qazvin University of Medical Sciences & Health Services
2023-01-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.qums.ac.ir/article-1-3312-en.pdf |
| _version_ | 1797674770642239488 |
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| author | Maryam Zamani1 Fariba Zafari2 Vahid Najafzadeh3 Rajaei Farzad Rajaei2 Mana Kamranjam1 Amir Hosseini *2 |
| author_facet | Maryam Zamani1 Fariba Zafari2 Vahid Najafzadeh3 Rajaei Farzad Rajaei2 Mana Kamranjam1 Amir Hosseini *2 |
| author_sort | Maryam Zamani1 |
| collection | DOAJ |
| description | A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress. Aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions, such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the cell, it causes a harmful effect called oxidative stress. This results in the oxidation of lipids, proteins, carbohydrates, and nucleotides. The production of ROS is increased by various factors, including the presence of leukocytes, sperms with abnormal and immature morphology, centrifugation of samples, and changes in oxygen concentration, pH, and temperature. Sperm freezing is a method widely used in assisted reproductive technology (ART) as well as infertility treatment. The process of freezing also contributes to increased oxidative stress because it alters the fluidity of the mitochondrial membrane, leading to increased production and release of ROS. Sperm have defense mechanisms against oxidative stress caused by increased ROS production, which includes the presence of enzymatic and non-enzymatic antioxidants in semen. The utilization of supplementary antioxidants in the freezing environment is a strategy to combat oxidative stress. This review aims to summarize the current evidence on the effect of antioxidants on sperm freezing. |
| first_indexed | 2024-03-11T22:03:54Z |
| format | Article |
| id | doaj.art-7f37ce5edeed4decbc07b2c575003cce |
| institution | Directory Open Access Journal |
| issn | 1561-3666 2228-7213 |
| language | fas |
| last_indexed | 2024-03-11T22:03:54Z |
| publishDate | 2023-01-01 |
| publisher | Qazvin University of Medical Sciences & Health Services |
| record_format | Article |
| series | The Journal of Qazvin University of Medical Sciences |
| spelling | doaj.art-7f37ce5edeed4decbc07b2c575003cce2023-09-25T10:06:37ZfasQazvin University of Medical Sciences & Health ServicesThe Journal of Qazvin University of Medical Sciences1561-36662228-72132023-01-01264217226http://dx.doi.org/10.32598/JID.26.4.7Effect of Antioxidant on Sperm FreezingMaryam Zamani10https://orcid.org/0000-0003-4120-7107Fariba Zafari21https://orcid.org/0000-0003-2061-2656Vahid Najafzadeh32https://orcid.org/0000-0001-6943-9327Rajaei Farzad Rajaei23https://orcid.org/0000-0002-6890-8846Mana Kamranjam14https://orcid.org/0000-0002-3840-4743Amir Hosseini *25https://orcid.org/0000-0003-2848-87171. Students’ Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran2. Cellular and Molecular Research Center, Research Institute for Presentation of Non-communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.3. Queensland Fertility Group Research Foundation, Spring Hill, Queensland, Australia2. Cellular and Molecular Research Center, Research Institute for Presentation of Non-communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.1. Students’ Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.2. Cellular and Molecular Research Center, Research Institute for Presentation of Non-communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress. Aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions, such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the cell, it causes a harmful effect called oxidative stress. This results in the oxidation of lipids, proteins, carbohydrates, and nucleotides. The production of ROS is increased by various factors, including the presence of leukocytes, sperms with abnormal and immature morphology, centrifugation of samples, and changes in oxygen concentration, pH, and temperature. Sperm freezing is a method widely used in assisted reproductive technology (ART) as well as infertility treatment. The process of freezing also contributes to increased oxidative stress because it alters the fluidity of the mitochondrial membrane, leading to increased production and release of ROS. Sperm have defense mechanisms against oxidative stress caused by increased ROS production, which includes the presence of enzymatic and non-enzymatic antioxidants in semen. The utilization of supplementary antioxidants in the freezing environment is a strategy to combat oxidative stress. This review aims to summarize the current evidence on the effect of antioxidants on sperm freezing. https://journal.qums.ac.ir/article-1-3312-en.pdfinfertilityantioxidantsperm freezingassisted reproductive technics |
| spellingShingle | Maryam Zamani1 Fariba Zafari2 Vahid Najafzadeh3 Rajaei Farzad Rajaei2 Mana Kamranjam1 Amir Hosseini *2 Effect of Antioxidant on Sperm Freezing The Journal of Qazvin University of Medical Sciences infertility antioxidant sperm freezing assisted reproductive technics |
| title | Effect of Antioxidant on Sperm Freezing |
| title_full | Effect of Antioxidant on Sperm Freezing |
| title_fullStr | Effect of Antioxidant on Sperm Freezing |
| title_full_unstemmed | Effect of Antioxidant on Sperm Freezing |
| title_short | Effect of Antioxidant on Sperm Freezing |
| title_sort | effect of antioxidant on sperm freezing |
| topic | infertility antioxidant sperm freezing assisted reproductive technics |
| url | https://journal.qums.ac.ir/article-1-3312-en.pdf |
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