Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex
A decline in the body’s motor functions has been linked to decreased muscle mass and function in the oral cavity and throat; however, aging of the junctions of the muscles and bones has also been identified as an associated factor. Basic and clinical studies on the muscles, tendons and bones, each c...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6365 |
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| author | Shinichi Abe Masahito Yamamoto |
| author_facet | Shinichi Abe Masahito Yamamoto |
| author_sort | Shinichi Abe |
| collection | DOAJ |
| description | A decline in the body’s motor functions has been linked to decreased muscle mass and function in the oral cavity and throat; however, aging of the junctions of the muscles and bones has also been identified as an associated factor. Basic and clinical studies on the muscles, tendons and bones, each considered independently, have been published. In recent years, however, research has focused on muscle attachment as the muscle–tendon–bone complex from various perspectives, and there is a growing body of knowledge on SRY-box9 (Sox9) and Mohawk(Mkx), which has been identified as a common controlling factor and a key element. Myostatin, a factor that inhibits muscle growth, has been identified as a potential key element in the mechanisms of lifetime structural maintenance of the muscle–tendon–bone complex. Findings in recent studies have also uncovered aspects of the mechanisms of motor organ complex morphostasis in the superaged society of today and will lay the groundwork for treatments to prevent motor function decline in older adults. |
| first_indexed | 2024-03-10T10:25:30Z |
| format | Article |
| id | doaj.art-7f392ef0f1c8454f83295d3822882224 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:25:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7f392ef0f1c8454f83295d38228822242023-11-22T00:04:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212636510.3390/ijms22126365Factors Involved in Morphogenesis in the Muscle–Tendon–Bone ComplexShinichi Abe0Masahito Yamamoto1Department of Anatomy, Tokyo Dental College, 2-9-18 Kanda-misakicho, Chiyoda-ku, Tokyo 101-0061, JapanDepartment of Anatomy, Tokyo Dental College, 2-9-18 Kanda-misakicho, Chiyoda-ku, Tokyo 101-0061, JapanA decline in the body’s motor functions has been linked to decreased muscle mass and function in the oral cavity and throat; however, aging of the junctions of the muscles and bones has also been identified as an associated factor. Basic and clinical studies on the muscles, tendons and bones, each considered independently, have been published. In recent years, however, research has focused on muscle attachment as the muscle–tendon–bone complex from various perspectives, and there is a growing body of knowledge on SRY-box9 (Sox9) and Mohawk(Mkx), which has been identified as a common controlling factor and a key element. Myostatin, a factor that inhibits muscle growth, has been identified as a potential key element in the mechanisms of lifetime structural maintenance of the muscle–tendon–bone complex. Findings in recent studies have also uncovered aspects of the mechanisms of motor organ complex morphostasis in the superaged society of today and will lay the groundwork for treatments to prevent motor function decline in older adults.https://www.mdpi.com/1422-0067/22/12/6365musculotendinous junctionenthesisSox9myostatin |
| spellingShingle | Shinichi Abe Masahito Yamamoto Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex International Journal of Molecular Sciences musculotendinous junction enthesis Sox9 myostatin |
| title | Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex |
| title_full | Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex |
| title_fullStr | Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex |
| title_full_unstemmed | Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex |
| title_short | Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex |
| title_sort | factors involved in morphogenesis in the muscle tendon bone complex |
| topic | musculotendinous junction enthesis Sox9 myostatin |
| url | https://www.mdpi.com/1422-0067/22/12/6365 |
| work_keys_str_mv | AT shinichiabe factorsinvolvedinmorphogenesisinthemuscletendonbonecomplex AT masahitoyamamoto factorsinvolvedinmorphogenesisinthemuscletendonbonecomplex |