Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing
In chronic obstructive pulmonary disease (COPD), exertional dyspnea, which increases with the disease’s progression, reduces exercise tolerance and limits physical activity, leading to a worsening prognosis. It is necessary to understand the diverse mechanisms of dyspnea and take appropriate measure...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/364 |
| _version_ | 1797395786856660992 |
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| author | Keisuke Miki |
| author_facet | Keisuke Miki |
| author_sort | Keisuke Miki |
| collection | DOAJ |
| description | In chronic obstructive pulmonary disease (COPD), exertional dyspnea, which increases with the disease’s progression, reduces exercise tolerance and limits physical activity, leading to a worsening prognosis. It is necessary to understand the diverse mechanisms of dyspnea and take appropriate measures to reduce exertional dyspnea, as COPD is a systemic disease with various comorbidities. A treatment focusing on the motor pathophysiology related to dyspnea may lead to improvements such as reducing dynamic lung hyperinflation, respiratory and metabolic acidosis, and eventually exertional dyspnea. However, without cardiopulmonary exercise testing (CPET), it may be difficult to understand the pathophysiological conditions during exercise. CPET facilitates understanding of the gas exchange and transport associated with respiration-circulation and even crosstalk with muscles, which is sometimes challenging, and provides information on COPD treatment strategies. For respiratory medicine department staff, CPET can play a significant role when treating patients with diseases that cause exertional dyspnea. This article outlines the advantages of using CPET to evaluate exertional dyspnea in patients with COPD. |
| first_indexed | 2024-03-09T00:39:35Z |
| format | Article |
| id | doaj.art-7f3b259761204e2cbd8e9439d33f1b48 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T00:39:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7f3b259761204e2cbd8e9439d33f1b482023-12-11T17:53:54ZengMDPI AGDiagnostics2075-44182021-02-0111236410.3390/diagnostics11020364Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise TestingKeisuke Miki0Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka, Osaka 560-8552, JapanIn chronic obstructive pulmonary disease (COPD), exertional dyspnea, which increases with the disease’s progression, reduces exercise tolerance and limits physical activity, leading to a worsening prognosis. It is necessary to understand the diverse mechanisms of dyspnea and take appropriate measures to reduce exertional dyspnea, as COPD is a systemic disease with various comorbidities. A treatment focusing on the motor pathophysiology related to dyspnea may lead to improvements such as reducing dynamic lung hyperinflation, respiratory and metabolic acidosis, and eventually exertional dyspnea. However, without cardiopulmonary exercise testing (CPET), it may be difficult to understand the pathophysiological conditions during exercise. CPET facilitates understanding of the gas exchange and transport associated with respiration-circulation and even crosstalk with muscles, which is sometimes challenging, and provides information on COPD treatment strategies. For respiratory medicine department staff, CPET can play a significant role when treating patients with diseases that cause exertional dyspnea. This article outlines the advantages of using CPET to evaluate exertional dyspnea in patients with COPD.https://www.mdpi.com/2075-4418/11/2/364acidosisbreathingcardiopulmonary exercise testingdynamic hyperinflationmuscleventilation |
| spellingShingle | Keisuke Miki Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing Diagnostics acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation |
| title | Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing |
| title_full | Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing |
| title_fullStr | Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing |
| title_full_unstemmed | Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing |
| title_short | Motor Pathophysiology Related to Dyspnea in COPD Evaluated by Cardiopulmonary Exercise Testing |
| title_sort | motor pathophysiology related to dyspnea in copd evaluated by cardiopulmonary exercise testing |
| topic | acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation |
| url | https://www.mdpi.com/2075-4418/11/2/364 |
| work_keys_str_mv | AT keisukemiki motorpathophysiologyrelatedtodyspneaincopdevaluatedbycardiopulmonaryexercisetesting |