Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model
Prior odor experience has a profound effect on the coding of new odor inputs by animals. The olfactory bulb, the first relay of the olfactory pathway, can substantially shape the representations of odor inputs. How prior odor experience affects the representation of new odor inputs in olfactory bulb...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00010/full |
| _version_ | 1819207019843813376 |
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| author | Shanglin eZhou Michele eMigliore Michele eMigliore Yuguo eYu |
| author_facet | Shanglin eZhou Michele eMigliore Michele eMigliore Yuguo eYu |
| author_sort | Shanglin eZhou |
| collection | DOAJ |
| description | Prior odor experience has a profound effect on the coding of new odor inputs by animals. The olfactory bulb, the first relay of the olfactory pathway, can substantially shape the representations of odor inputs. How prior odor experience affects the representation of new odor inputs in olfactory bulb and its underlying network mechanism are still unclear. Here we carried out a series of simulations based on a large-scale realistic mitral-granule network model and found that prior odor experience not only accelerated formation of the network, but it also significantly strengthened sparse responses in the mitral cell network while decreasing sparse responses in the granule cell network. This modulation of sparse representations may be due to the increase of inhibitory synaptic weights. Correlations among mitral cells within the network and correlations between mitral network responses to different odors decreased gradually when the number of prior training odors was increased, resulting in a greater decorrelation of the bulb representations of input odors. Based on these findings, we conclude that the degree of prior odor experience facilitates degrees of sparse representations of new odors by the mitral cell network through experience-enhanced inhibition mechanism. |
| first_indexed | 2024-12-23T05:16:51Z |
| format | Article |
| id | doaj.art-7f3c050cabd5467fb08b0c5ad7c9448d |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-23T05:16:51Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-7f3c050cabd5467fb08b0c5ad7c9448d2022-12-21T17:58:48ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292016-02-011010.3389/fnana.2016.00010166556Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb modelShanglin eZhou0Michele eMigliore1Michele eMigliore2Yuguo eYu3Fudan universityInstitute of Biophysics, National Research CouncilYale University School of MedicineFudan universityPrior odor experience has a profound effect on the coding of new odor inputs by animals. The olfactory bulb, the first relay of the olfactory pathway, can substantially shape the representations of odor inputs. How prior odor experience affects the representation of new odor inputs in olfactory bulb and its underlying network mechanism are still unclear. Here we carried out a series of simulations based on a large-scale realistic mitral-granule network model and found that prior odor experience not only accelerated formation of the network, but it also significantly strengthened sparse responses in the mitral cell network while decreasing sparse responses in the granule cell network. This modulation of sparse representations may be due to the increase of inhibitory synaptic weights. Correlations among mitral cells within the network and correlations between mitral network responses to different odors decreased gradually when the number of prior training odors was increased, resulting in a greater decorrelation of the bulb representations of input odors. Based on these findings, we conclude that the degree of prior odor experience facilitates degrees of sparse representations of new odors by the mitral cell network through experience-enhanced inhibition mechanism.http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00010/fullOlfactory Bulbodor codingsparse representationPrior experiencelarge scale network. |
| spellingShingle | Shanglin eZhou Michele eMigliore Michele eMigliore Yuguo eYu Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model Frontiers in Neuroanatomy Olfactory Bulb odor coding sparse representation Prior experience large scale network. |
| title | Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model |
| title_full | Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model |
| title_fullStr | Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model |
| title_full_unstemmed | Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model |
| title_short | Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model |
| title_sort | odor experience facilitates sparse representations of new odors in a large scale olfactory bulb model |
| topic | Olfactory Bulb odor coding sparse representation Prior experience large scale network. |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00010/full |
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