Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy
Abstract Background Urinary system anomalies, both congenital and acquired, constitute a relatively common clinical problem in children. The main role of diagnostic imaging is to determine early diagnosis and support therapeutic decisions to prevent the development of chronic renal disease. The aim...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-04694-2 |
| _version_ | 1797233261441712128 |
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| author | Małgorzata Gołuch Agnieszka Pytlewska Jędrzej Sarnecki Paulina Chodnicka Anna Śliwińska Łukasz Obrycki Elżbieta Jurkiewicz |
| author_facet | Małgorzata Gołuch Agnieszka Pytlewska Jędrzej Sarnecki Paulina Chodnicka Anna Śliwińska Łukasz Obrycki Elżbieta Jurkiewicz |
| author_sort | Małgorzata Gołuch |
| collection | DOAJ |
| description | Abstract Background Urinary system anomalies, both congenital and acquired, constitute a relatively common clinical problem in children. The main role of diagnostic imaging is to determine early diagnosis and support therapeutic decisions to prevent the development of chronic renal disease. The aim of this study was to evaluate the utility of magnetic resonance urography (MRU) in assessment of urinary system in children, by comparing differential renal function calculated using MRU with dynamic renal scintigraphy (DRS). Materials and methods The study group consisted of 46 patients aged 1 week to 17 years (median 7 (0.5; 13) years, 17 (37%) girls, 29 (63%) boys), who underwent dynamic renal scintigraphy due to various clinical reasons. All participants underwent MRU, which was used to measure differential renal function. Functional analysis was performed using dedicated external software (CHOP-fMRU and pMRI without prior knowledge of DRS results. MRU results acquired using pMRI were assessed for inter and intraobserver agreement. Results Statistical analysis of the results showed excellent agreement between MRU and DRS in measuring differential renal function with Pearson correlation coefficient 0.987 for CHOP-fMRU and 0.971 for pMRI, p < 0.001. Interclass correlation coefficient (ICC) for these programs was 0.987 (95% CI 0.976–0.993) and 0.969 (95% CI 0.945–0.983) respectively, p < 0.001. The Bland-Altman 95% limits of agreement for CHOP-fMRU results vs. DRS was − 6.29–5.50 p.p. and for pMRI results vs. DRS − 9.15–9.63 p.p. The differential renal function measurements calculated in pMRI showed excellent intraobserver and interobserver agreement with ICC 0.996 (95% CI 0.994–0.998) and 0.992 (95% CI 0.986–0.996) respectively, p < 0.001. Conclusions The study showed no significant differences between magnetic resonance urography and dynamic renal scintigraphy in calculating differential renal function. It indicates high utility of MRU in the evaluation of urinary system in children. |
| first_indexed | 2024-04-24T16:13:22Z |
| format | Article |
| id | doaj.art-7f3c26d410f04e39acb0752d79bb6287 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-24T16:13:22Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-7f3c26d410f04e39acb0752d79bb62872024-03-31T11:35:49ZengBMCBMC Pediatrics1471-24312024-03-012411910.1186/s12887-024-04694-2Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphyMałgorzata Gołuch0Agnieszka Pytlewska1Jędrzej Sarnecki2Paulina Chodnicka3Anna Śliwińska4Łukasz Obrycki5Elżbieta Jurkiewicz6Department of Diagnostic Imaging, The Children’s Memorial Health InstituteDepartment of Diagnostic Imaging, The Children’s Memorial Health InstituteDepartment of Radiology, University Hospital BaselDepartment of Diagnostic Imaging, The Children’s Memorial Health InstituteDepartment of Nuclear Medicine, The Children’s Memorial Health InstituteDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children’s Memorial Health InstituteDepartment of Diagnostic Imaging, The Children’s Memorial Health InstituteAbstract Background Urinary system anomalies, both congenital and acquired, constitute a relatively common clinical problem in children. The main role of diagnostic imaging is to determine early diagnosis and support therapeutic decisions to prevent the development of chronic renal disease. The aim of this study was to evaluate the utility of magnetic resonance urography (MRU) in assessment of urinary system in children, by comparing differential renal function calculated using MRU with dynamic renal scintigraphy (DRS). Materials and methods The study group consisted of 46 patients aged 1 week to 17 years (median 7 (0.5; 13) years, 17 (37%) girls, 29 (63%) boys), who underwent dynamic renal scintigraphy due to various clinical reasons. All participants underwent MRU, which was used to measure differential renal function. Functional analysis was performed using dedicated external software (CHOP-fMRU and pMRI without prior knowledge of DRS results. MRU results acquired using pMRI were assessed for inter and intraobserver agreement. Results Statistical analysis of the results showed excellent agreement between MRU and DRS in measuring differential renal function with Pearson correlation coefficient 0.987 for CHOP-fMRU and 0.971 for pMRI, p < 0.001. Interclass correlation coefficient (ICC) for these programs was 0.987 (95% CI 0.976–0.993) and 0.969 (95% CI 0.945–0.983) respectively, p < 0.001. The Bland-Altman 95% limits of agreement for CHOP-fMRU results vs. DRS was − 6.29–5.50 p.p. and for pMRI results vs. DRS − 9.15–9.63 p.p. The differential renal function measurements calculated in pMRI showed excellent intraobserver and interobserver agreement with ICC 0.996 (95% CI 0.994–0.998) and 0.992 (95% CI 0.986–0.996) respectively, p < 0.001. Conclusions The study showed no significant differences between magnetic resonance urography and dynamic renal scintigraphy in calculating differential renal function. It indicates high utility of MRU in the evaluation of urinary system in children.https://doi.org/10.1186/s12887-024-04694-2Magnetic resonance urographyDifferential renal functionDynamic renal scintigraphyPelvicalyceal dilatationCAKUTPediatric urology |
| spellingShingle | Małgorzata Gołuch Agnieszka Pytlewska Jędrzej Sarnecki Paulina Chodnicka Anna Śliwińska Łukasz Obrycki Elżbieta Jurkiewicz Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy BMC Pediatrics Magnetic resonance urography Differential renal function Dynamic renal scintigraphy Pelvicalyceal dilatation CAKUT Pediatric urology |
| title | Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| title_full | Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| title_fullStr | Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| title_full_unstemmed | Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| title_short | Evaluation of differential renal function in children – a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| title_sort | evaluation of differential renal function in children a comparative study between magnetic resonance urography and dynamic renal scintigraphy |
| topic | Magnetic resonance urography Differential renal function Dynamic renal scintigraphy Pelvicalyceal dilatation CAKUT Pediatric urology |
| url | https://doi.org/10.1186/s12887-024-04694-2 |
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