Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors
Key Clinical Message Recent data reveal phenotypic HoFH patients may be responsive to PCSK9 inhibitors, challenging prior assumptions. Genetic testing advancements now more accurately forecast patient responses to these therapies, improving treatment strategies.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.8537 |
| _version_ | 1797291572768800768 |
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| author | Ryosuke Tani Keiji Matsunaga Yuta Toda Tomoko Inoue Hai Ying Fu Tetsuo Minamino |
| author_facet | Ryosuke Tani Keiji Matsunaga Yuta Toda Tomoko Inoue Hai Ying Fu Tetsuo Minamino |
| author_sort | Ryosuke Tani |
| collection | DOAJ |
| description | Key Clinical Message Recent data reveal phenotypic HoFH patients may be responsive to PCSK9 inhibitors, challenging prior assumptions. Genetic testing advancements now more accurately forecast patient responses to these therapies, improving treatment strategies. |
| first_indexed | 2024-03-07T19:38:44Z |
| format | Article |
| id | doaj.art-7f3ca748946b492aaae9ac70e581b18c |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-07T19:38:44Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-7f3ca748946b492aaae9ac70e581b18c2024-02-29T07:13:21ZengWileyClinical Case Reports2050-09042024-02-01122n/an/a10.1002/ccr3.8537Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitorsRyosuke Tani0Keiji Matsunaga1Yuta Toda2Tomoko Inoue3Hai Ying Fu4Tetsuo Minamino5Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine Kagawa University Kagawa JapanKey Clinical Message Recent data reveal phenotypic HoFH patients may be responsive to PCSK9 inhibitors, challenging prior assumptions. Genetic testing advancements now more accurately forecast patient responses to these therapies, improving treatment strategies.https://doi.org/10.1002/ccr3.8537genetic testinghomozygous familial hypercholesterolemiapediatric familial hypercholesterolemiaproprotein convertase subtilisin/kexin type 9 inhibitors |
| spellingShingle | Ryosuke Tani Keiji Matsunaga Yuta Toda Tomoko Inoue Hai Ying Fu Tetsuo Minamino Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors Clinical Case Reports genetic testing homozygous familial hypercholesterolemia pediatric familial hypercholesterolemia proprotein convertase subtilisin/kexin type 9 inhibitors |
| title | Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors |
| title_full | Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors |
| title_fullStr | Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors |
| title_full_unstemmed | Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors |
| title_short | Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors |
| title_sort | phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin kexin type 9 inhibitors |
| topic | genetic testing homozygous familial hypercholesterolemia pediatric familial hypercholesterolemia proprotein convertase subtilisin/kexin type 9 inhibitors |
| url | https://doi.org/10.1002/ccr3.8537 |
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