Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
Abstract Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensiv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13659-023-00376-1 |
| _version_ | 1797849842120130560 |
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| author | Qi-Qi Zhang Kun Hu Han-Dong Sun Pema-Tenzin Puno |
| author_facet | Qi-Qi Zhang Kun Hu Han-Dong Sun Pema-Tenzin Puno |
| author_sort | Qi-Qi Zhang |
| collection | DOAJ |
| description | Abstract Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. Graphical Abstract |
| first_indexed | 2024-04-09T18:50:42Z |
| format | Article |
| id | doaj.art-7f40543be3904888bb25bd74eb22796a |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-04-09T18:50:42Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-7f40543be3904888bb25bd74eb22796a2023-04-09T11:29:51ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092023-04-011311810.1007/s13659-023-00376-1Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccineaQi-Qi Zhang0Kun Hu1Han-Dong Sun2Pema-Tenzin Puno3State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. Graphical Abstracthttps://doi.org/10.1007/s13659-023-00376-1Kadsura coccineaLanostane triterpenoidsExtended π-conjugated systemsQuantum chemical calculation |
| spellingShingle | Qi-Qi Zhang Kun Hu Han-Dong Sun Pema-Tenzin Puno Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea Natural Products and Bioprospecting Kadsura coccinea Lanostane triterpenoids Extended π-conjugated systems Quantum chemical calculation |
| title | Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea |
| title_full | Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea |
| title_fullStr | Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea |
| title_full_unstemmed | Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea |
| title_short | Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea |
| title_sort | four new lanostane triterpenoids featuring extended π conjugated systems from the stems of kadsura coccinea |
| topic | Kadsura coccinea Lanostane triterpenoids Extended π-conjugated systems Quantum chemical calculation |
| url | https://doi.org/10.1007/s13659-023-00376-1 |
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