Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases
The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356152/full |
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| author | Junyuan Yan Junyuan Yan Junyuan Yan Xinqin Zhong Xinqin Zhong Xinqin Zhong Yucui Zhao Yucui Zhao Yucui Zhao Xiaoying Wang Xiaoying Wang Xiaoying Wang |
| author_facet | Junyuan Yan Junyuan Yan Junyuan Yan Xinqin Zhong Xinqin Zhong Xinqin Zhong Yucui Zhao Yucui Zhao Yucui Zhao Xiaoying Wang Xiaoying Wang Xiaoying Wang |
| author_sort | Junyuan Yan |
| collection | DOAJ |
| description | The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases. MiRNAs are a class of noncoding single-strand RNA molecules typically 21–23 nucleotides in length that are encoded by endogenous genes. They are critical regulators of organism development, cell differentiation, metabolism, and apoptosis. Current clinical trials on miRNA drugs indicate that patient-specific miRNA levels are now being used as one of the criteria for predicting heart disease. However, the cellular process of various miRNAs in CMECs in cardiovascular diseases has not been fully elucidated. These mechanisms are a field that immediately requires further investigation. Accordingly, this review summarizes the roles and mechanisms of various miRNAs in CMECs in cardiovascular disease and includes the process of CMEC crosstalk between miRNAs and other cell types in the heart. Our study serves as a theoretical basis for the formal introduction of miRNA use into the treatment of cardiovascular diseases in the future. |
| first_indexed | 2024-04-25T00:14:37Z |
| format | Article |
| id | doaj.art-7f412cc7e55440318ee4392a8946fe0a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-25T00:14:37Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7f412cc7e55440318ee4392a8946fe0a2024-03-13T04:59:01ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-03-011110.3389/fcvm.2024.13561521356152Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseasesJunyuan Yan0Junyuan Yan1Junyuan Yan2Xinqin Zhong3Xinqin Zhong4Xinqin Zhong5Yucui Zhao6Yucui Zhao7Yucui Zhao8Xiaoying Wang9Xiaoying Wang10Xiaoying Wang11Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaMinistry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaMinistry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaMinistry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaThe occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases. MiRNAs are a class of noncoding single-strand RNA molecules typically 21–23 nucleotides in length that are encoded by endogenous genes. They are critical regulators of organism development, cell differentiation, metabolism, and apoptosis. Current clinical trials on miRNA drugs indicate that patient-specific miRNA levels are now being used as one of the criteria for predicting heart disease. However, the cellular process of various miRNAs in CMECs in cardiovascular diseases has not been fully elucidated. These mechanisms are a field that immediately requires further investigation. Accordingly, this review summarizes the roles and mechanisms of various miRNAs in CMECs in cardiovascular disease and includes the process of CMEC crosstalk between miRNAs and other cell types in the heart. Our study serves as a theoretical basis for the formal introduction of miRNA use into the treatment of cardiovascular diseases in the future.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356152/fullcardiac microvascular endothelial cellmiRNAcoronary artery diseasemicrovascular dysfunctiondiabetescrosstalk |
| spellingShingle | Junyuan Yan Junyuan Yan Junyuan Yan Xinqin Zhong Xinqin Zhong Xinqin Zhong Yucui Zhao Yucui Zhao Yucui Zhao Xiaoying Wang Xiaoying Wang Xiaoying Wang Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases Frontiers in Cardiovascular Medicine cardiac microvascular endothelial cell miRNA coronary artery disease microvascular dysfunction diabetes crosstalk |
| title | Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases |
| title_full | Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases |
| title_fullStr | Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases |
| title_full_unstemmed | Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases |
| title_short | Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases |
| title_sort | role and mechanism of mirna in cardiac microvascular endothelial cells in cardiovascular diseases |
| topic | cardiac microvascular endothelial cell miRNA coronary artery disease microvascular dysfunction diabetes crosstalk |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356152/full |
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