Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/3/653 |
| _version_ | 1797443566578958336 |
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| author | Elisa-Racky N’Diaye Nicola Salvatore Orefice Catherine Ghezzi Ahcène Boumendjel |
| author_facet | Elisa-Racky N’Diaye Nicola Salvatore Orefice Catherine Ghezzi Ahcène Boumendjel |
| author_sort | Elisa-Racky N’Diaye |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs’ rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs’ use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers. |
| first_indexed | 2024-03-09T12:57:56Z |
| format | Article |
| id | doaj.art-7f45d4fd8f1a45f5be2a1cde41175f8f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:57:56Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7f45d4fd8f1a45f5be2a1cde41175f8f2023-11-30T21:58:00ZengMDPI AGPharmaceutics1999-49232022-03-0114365310.3390/pharmaceutics14030653Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug DeliveryElisa-Racky N’Diaye0Nicola Salvatore Orefice1Catherine Ghezzi2Ahcène Boumendjel3Faculty of Pharmacy, Université Grenoble Alpes, 38700 La Tronche, FranceLaboratoire Radiopharmaceutiques Biocliniques (LRB), INSERM U1039, Faculté de Médecine La Tronche, Université Grenoble Alpes, 38000 Grenoble, FranceLaboratoire Radiopharmaceutiques Biocliniques (LRB), INSERM U1039, Faculté de Médecine La Tronche, Université Grenoble Alpes, 38000 Grenoble, FranceLaboratoire Radiopharmaceutiques Biocliniques (LRB), INSERM U1039, Faculté de Médecine La Tronche, Université Grenoble Alpes, 38000 Grenoble, FranceExtracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs’ rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs’ use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers.https://www.mdpi.com/1999-4923/14/3/653extracellular vesiclesnanoparticlesdrug deliveryradiolabeling |
| spellingShingle | Elisa-Racky N’Diaye Nicola Salvatore Orefice Catherine Ghezzi Ahcène Boumendjel Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery Pharmaceutics extracellular vesicles nanoparticles drug delivery radiolabeling |
| title | Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery |
| title_full | Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery |
| title_fullStr | Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery |
| title_full_unstemmed | Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery |
| title_short | Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery |
| title_sort | chemically modified extracellular vesicles and applications in radiolabeling and drug delivery |
| topic | extracellular vesicles nanoparticles drug delivery radiolabeling |
| url | https://www.mdpi.com/1999-4923/14/3/653 |
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