Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration
Aim: To determine of parodontium state of rat, which received cariesogenic ration and different doses of octenidine hexafluorosilicate (O-HFS). Methods: The octenidine hexafluorosilicate was synthesized by us and was used into mucoso-adgesive gels (Na-CMC) in next concentrations: 1 mg/ml, 2 mg/ml...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2017-06-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/24264 |
| _version_ | 1818049118994432000 |
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| author | V. Yu. Anisimov |
| author_facet | V. Yu. Anisimov |
| author_sort | V. Yu. Anisimov |
| collection | DOAJ |
| description |
Aim: To determine of parodontium state of rat, which received cariesogenic ration and different doses of octenidine hexafluorosilicate (O-HFS).
Methods: The octenidine hexafluorosilicate was synthesized by us and was used into mucoso-adgesive gels (Na-CMC) in next concentrations: 1 mg/ml, 2 mg/ml and 4 mg/ml. The rats received high-sugar cariesogenic ration and oral applications of gels with O-HFS in doses of 0,3 ml (daily doses of O-HFS were 1,4 mg/kg, 2,8 mg/kg and 5,6 mg/kg). The duration of experiment was 35 days. The activities of urease, lysozyme and elastase were determined into gum. The activities of urease, lysozyme, ALT and alkaline phosphatase (APh) were determined into serum. The degree of dysbiosis calculated by ration urease and lysozyme. The degree of atrophy of parodontale bone was determined by Nicolaeva method.
Results: The activities of elastase and urease, the degree of atrophy and dysbiosis were raised into gum of rat, which received cariesogenic ration. The activities of ALT and APh, the degree of dysbiosis were raised into serum. The oral application of O-HFS-gels decreased the all these indices. The maximal action made O-HFS-gel in dose 2,8 mg/kg.
Conclusion: The oral application of O-HFS-gel make parodontoprotective action.
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| first_indexed | 2024-12-10T10:32:30Z |
| format | Article |
| id | doaj.art-7f468feebeea4d66a0938cb953744154 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-10T10:32:30Z |
| publishDate | 2017-06-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-7f468feebeea4d66a0938cb9537441542022-12-22T01:52:32ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-06-0176Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic rationV. Yu. Anisimov0Odessa National Medical University Aim: To determine of parodontium state of rat, which received cariesogenic ration and different doses of octenidine hexafluorosilicate (O-HFS). Methods: The octenidine hexafluorosilicate was synthesized by us and was used into mucoso-adgesive gels (Na-CMC) in next concentrations: 1 mg/ml, 2 mg/ml and 4 mg/ml. The rats received high-sugar cariesogenic ration and oral applications of gels with O-HFS in doses of 0,3 ml (daily doses of O-HFS were 1,4 mg/kg, 2,8 mg/kg and 5,6 mg/kg). The duration of experiment was 35 days. The activities of urease, lysozyme and elastase were determined into gum. The activities of urease, lysozyme, ALT and alkaline phosphatase (APh) were determined into serum. The degree of dysbiosis calculated by ration urease and lysozyme. The degree of atrophy of parodontale bone was determined by Nicolaeva method. Results: The activities of elastase and urease, the degree of atrophy and dysbiosis were raised into gum of rat, which received cariesogenic ration. The activities of ALT and APh, the degree of dysbiosis were raised into serum. The oral application of O-HFS-gels decreased the all these indices. The maximal action made O-HFS-gel in dose 2,8 mg/kg. Conclusion: The oral application of O-HFS-gel make parodontoprotective action. https://apcz.umk.pl/JEHS/article/view/24264hexafluorosilicateperiodontiumdysbiosisinflammationmucoso-adgesive gel |
| spellingShingle | V. Yu. Anisimov Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration Journal of Education, Health and Sport hexafluorosilicate periodontium dysbiosis inflammation mucoso-adgesive gel |
| title | Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration |
| title_full | Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration |
| title_fullStr | Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration |
| title_full_unstemmed | Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration |
| title_short | Influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat, which received cariesogenic ration |
| title_sort | influence of different doses of octenidine hexafluorosilicate on parodontotium state of rat which received cariesogenic ration |
| topic | hexafluorosilicate periodontium dysbiosis inflammation mucoso-adgesive gel |
| url | https://apcz.umk.pl/JEHS/article/view/24264 |
| work_keys_str_mv | AT vyuanisimov influenceofdifferentdosesofoctenidinehexafluorosilicateonparodontotiumstateofratwhichreceivedcariesogenicration |