OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms
Background: The electroretinogram is a clinical test used to assess the function of the photoreceptors and retinal circuits of various cells in the eye, with the recorded waveform being the result of the summated response of neural generators across the retina. Methods: The present investigation inv...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/6/708 |
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| author | Aleksei Zhdanov Paul Constable Sultan Mohammad Manjur Anton Dolganov Hugo F. Posada-Quintero Aleksander Lizunov |
| author_facet | Aleksei Zhdanov Paul Constable Sultan Mohammad Manjur Anton Dolganov Hugo F. Posada-Quintero Aleksander Lizunov |
| author_sort | Aleksei Zhdanov |
| collection | DOAJ |
| description | Background: The electroretinogram is a clinical test used to assess the function of the photoreceptors and retinal circuits of various cells in the eye, with the recorded waveform being the result of the summated response of neural generators across the retina. Methods: The present investigation involved an analysis of the electroretinogram waveform in both the time and time–frequency domains through the utilization of the discrete wavelet transform and continuous wavelet transform techniques. The primary aim of this study was to monitor and evaluate the effects of treatment in a New Zealand rabbit model of endophthalmitis via electroretinogram waveform analysis and to compare these with normal human electroretinograms. Results: The wavelet scalograms were analyzed using various mother wavelets, including the Daubechies, Ricker, Wavelet Biorthogonal 3.1 (bior3.1), Morlet, Haar, and Gaussian wavelets. Distinctive variances were identified in the wavelet scalograms between rabbit and human electroretinograms. The wavelet scalograms in the rabbit model of endophthalmitis showed recovery with treatment in parallel with the time-domain features. Conclusions: The study compared adult, child, and rabbit electroretinogram responses using DWT and CWT, finding that adult signals had higher power than child signals, and that rabbit signals showed differences in the a-wave and b-wave depending on the type of response tested, while the Haar wavelet was found to be superior in visualizing frequency components in electrophysiological signals for following the treatment of endophthalmitis and may give additional outcome measures for the management of retinal disease. |
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| language | English |
| last_indexed | 2024-03-11T02:45:45Z |
| publishDate | 2023-06-01 |
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| series | Bioengineering |
| spelling | doaj.art-7f479d31294c4c19b0a5fc8b0de577322023-11-18T09:21:39ZengMDPI AGBioengineering2306-53542023-06-0110670810.3390/bioengineering10060708OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet TransformsAleksei Zhdanov0Paul Constable1Sultan Mohammad Manjur2Anton Dolganov3Hugo F. Posada-Quintero4Aleksander Lizunov5Machine Learning and Data Analytics Lab, University of Erlangen-Nuremberg, 91052 Erlangen, GermanyCollege of Nursing and Health Sciences, Caring Futures Institute, Flinders University, Adelaide, SA 5042, AustraliaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USAEngineering School of Information Technologies, Telecommunications and Control Systems, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Yekaterinburg, RussiaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Functional Diagnostics, IRTC Eye Microsurgery Ekaterinburg Center, 620149 Yekaterinburg, RussiaBackground: The electroretinogram is a clinical test used to assess the function of the photoreceptors and retinal circuits of various cells in the eye, with the recorded waveform being the result of the summated response of neural generators across the retina. Methods: The present investigation involved an analysis of the electroretinogram waveform in both the time and time–frequency domains through the utilization of the discrete wavelet transform and continuous wavelet transform techniques. The primary aim of this study was to monitor and evaluate the effects of treatment in a New Zealand rabbit model of endophthalmitis via electroretinogram waveform analysis and to compare these with normal human electroretinograms. Results: The wavelet scalograms were analyzed using various mother wavelets, including the Daubechies, Ricker, Wavelet Biorthogonal 3.1 (bior3.1), Morlet, Haar, and Gaussian wavelets. Distinctive variances were identified in the wavelet scalograms between rabbit and human electroretinograms. The wavelet scalograms in the rabbit model of endophthalmitis showed recovery with treatment in parallel with the time-domain features. Conclusions: The study compared adult, child, and rabbit electroretinogram responses using DWT and CWT, finding that adult signals had higher power than child signals, and that rabbit signals showed differences in the a-wave and b-wave depending on the type of response tested, while the Haar wavelet was found to be superior in visualizing frequency components in electrophysiological signals for following the treatment of endophthalmitis and may give additional outcome measures for the management of retinal disease.https://www.mdpi.com/2306-5354/10/6/708biomedical researchelectroretinographyelectroretinogramERGelectrophysiology |
| spellingShingle | Aleksei Zhdanov Paul Constable Sultan Mohammad Manjur Anton Dolganov Hugo F. Posada-Quintero Aleksander Lizunov OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms Bioengineering biomedical research electroretinography electroretinogram ERG electrophysiology |
| title | OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms |
| title_full | OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms |
| title_fullStr | OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms |
| title_full_unstemmed | OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms |
| title_short | OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms |
| title_sort | oculusgraphy signal analysis of the electroretinogram in a rabbit model of endophthalmitis using discrete and continuous wavelet transforms |
| topic | biomedical research electroretinography electroretinogram ERG electrophysiology |
| url | https://www.mdpi.com/2306-5354/10/6/708 |
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