Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers
Purpose: To evaluate the diagnostic performance of 18F-flurodeoxyglucose positron emission tomography/contrast enhanced computed tomography (18F-FDG PET/CT) in patients with clinically/radiologically suspected ovarian tumor recurrence and normal tumor markers. Materials and methods: A total of 54 18...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16301589 |
| _version_ | 1818503719524761600 |
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| author | Yasser Abdelhafez Ahmed Tawakol Amr Osama Emad Hamada Sherif El-Refaei |
| author_facet | Yasser Abdelhafez Ahmed Tawakol Amr Osama Emad Hamada Sherif El-Refaei |
| author_sort | Yasser Abdelhafez |
| collection | DOAJ |
| description | Purpose: To evaluate the diagnostic performance of 18F-flurodeoxyglucose positron emission tomography/contrast enhanced computed tomography (18F-FDG PET/CT) in patients with clinically/radiologically suspected ovarian tumor recurrence and normal tumor markers.
Materials and methods: A total of 54 18F-FDG PET/CT studies from 41 patients with suspected ovarian tumor recurrence and normal tumor markers were evaluated. Each patient underwent PET/CT with CE-CT scans in the same study. Studies were read independently by one experienced nuclear medicine physician and one experienced radiologist. A four-point score (score 0 = definitely benign, score 1 = probably benign, score 2 = probably malignant and score 3 = definitely malignant) used to assess the presence or absence of recurrence (local, regional or distant). The final diagnosis of tumor status was made on the basis of subsequent follow-up by conventional imaging (CT/MRI), 18F-18F-FDG PET/CT or histopathology whenever possible.
Results: Of the 54 studies evaluated, 26 (48%) studies had tumor recurrence and 28 (52%) studies were disease-free based on final diagnosis.
Combined 18F-FDG PET/CT vs. CE-CT alone showed sensitivity, specificity and accuracy of 92% vs. 73%, 90% vs. 55%, and 91% vs. 63%, respectively. 18F-18F-FDG PET/CT was significantly more sensitive, more specific and more accurate compared to CE-CT with P-values of 0.06, 0.006 and 0.0001, respectively. Site-based analyses were also performed and showed significantly higher diagnostic indices for combined FDG-PET/CT.
Conclusion: Combined 18F-FDG PET/CT with contrast enhancement is more accurate than CE-CT alone in the diagnosis of ovarian tumor recurrence in patients with normal tumor markers. |
| first_indexed | 2024-12-10T21:27:43Z |
| format | Article |
| id | doaj.art-7f47aab9ba1043c0b37f81e22ba7f4ae |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-10T21:27:43Z |
| publishDate | 2016-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-7f47aab9ba1043c0b37f81e22ba7f4ae2022-12-22T01:32:56ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-12-014741787179410.1016/j.ejrnm.2016.08.013Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markersYasser Abdelhafez0Ahmed Tawakol1Amr Osama2Emad Hamada3Sherif El-Refaei4Nuclear Medicine Unit, South Egypt Cancer Institute, Assiut University, Al Methaq Street, PO 71516, Assiut, EgyptNuclear Medicine Unit, Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Cairo University, Cairo, EgyptRadiology Department, Faculty of Medicine, Cairo University, Cairo, EgyptOncology Department, Faculty of Medicine, Cairo University, Cairo, EgyptNuclear Medicine Unit, Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Cairo University, Cairo, EgyptPurpose: To evaluate the diagnostic performance of 18F-flurodeoxyglucose positron emission tomography/contrast enhanced computed tomography (18F-FDG PET/CT) in patients with clinically/radiologically suspected ovarian tumor recurrence and normal tumor markers. Materials and methods: A total of 54 18F-FDG PET/CT studies from 41 patients with suspected ovarian tumor recurrence and normal tumor markers were evaluated. Each patient underwent PET/CT with CE-CT scans in the same study. Studies were read independently by one experienced nuclear medicine physician and one experienced radiologist. A four-point score (score 0 = definitely benign, score 1 = probably benign, score 2 = probably malignant and score 3 = definitely malignant) used to assess the presence or absence of recurrence (local, regional or distant). The final diagnosis of tumor status was made on the basis of subsequent follow-up by conventional imaging (CT/MRI), 18F-18F-FDG PET/CT or histopathology whenever possible. Results: Of the 54 studies evaluated, 26 (48%) studies had tumor recurrence and 28 (52%) studies were disease-free based on final diagnosis. Combined 18F-FDG PET/CT vs. CE-CT alone showed sensitivity, specificity and accuracy of 92% vs. 73%, 90% vs. 55%, and 91% vs. 63%, respectively. 18F-18F-FDG PET/CT was significantly more sensitive, more specific and more accurate compared to CE-CT with P-values of 0.06, 0.006 and 0.0001, respectively. Site-based analyses were also performed and showed significantly higher diagnostic indices for combined FDG-PET/CT. Conclusion: Combined 18F-FDG PET/CT with contrast enhancement is more accurate than CE-CT alone in the diagnosis of ovarian tumor recurrence in patients with normal tumor markers.http://www.sciencedirect.com/science/article/pii/S0378603X16301589FDG PET/CTContrast enhanced CTOvarian cancersNormal tumor markers |
| spellingShingle | Yasser Abdelhafez Ahmed Tawakol Amr Osama Emad Hamada Sherif El-Refaei Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers The Egyptian Journal of Radiology and Nuclear Medicine FDG PET/CT Contrast enhanced CT Ovarian cancers Normal tumor markers |
| title | Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| title_full | Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| title_fullStr | Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| title_full_unstemmed | Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| title_short | Role of 18F-FDG PET/CT in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| title_sort | role of 18f fdg pet ct in the detection of ovarian cancer recurrence in the setting of normal tumor markers |
| topic | FDG PET/CT Contrast enhanced CT Ovarian cancers Normal tumor markers |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16301589 |
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