Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report
This is the case report of a 39-year-old lady who presented with clinical and laboratory features of secondary hypothyroidism two years after achieving clinical and biochemical resolution of Graves' disease and cessation of anti-thyroid medications. The thyroid function tests at presentation re...
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| Format: | Article |
| Language: | English |
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Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu
2022-12-01
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| Series: | Annals of Health Research |
| Subjects: | |
| Online Access: | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/444 |
| _version_ | 1811173022590042112 |
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| author | Lawal Y Kaoje YS Bansi IK |
| author_facet | Lawal Y Kaoje YS Bansi IK |
| author_sort | Lawal Y |
| collection | DOAJ |
| description | This is the case report of a 39-year-old lady who presented with clinical and laboratory features of secondary hypothyroidism two years after achieving clinical and biochemical resolution of Graves' disease and cessation of anti-thyroid medications. The thyroid function tests at presentation revealed: Serum T3 1.33ng/ml (normal range 0.8-1.7ng/ml), Serum T4 2.92 (normal range 4.5-12.0µg/dl), and TSH 0.2mIU/l (normal range 0.5-5.0mIU/l). Thyroid-related autoantibodies could not be assayed in the patient due to financial constraints. However, pointers to the possible autoimmune nature of secondary hypothyroidism include the recurrence of exophthalmos, dating of symptoms back to puerperium, relative lymphocytosis, and moderately elevated erythrocyte sedimentation rate (ESR). The patient was subsequently placed on levothyroxine and low-dose steroids, and the patient achieved clinical and biochemical euthyroidism in the sixth, ninth, and twelfth months of follow-up. This report is to demonstrate the development of secondary hypothyroidism following Graves' disease, and it also serves to highlight the judicious use of clinical acumen in the face of limited laboratory support to diagnose and treat endocrine disorders in resource-poor settings. |
| first_indexed | 2024-04-10T17:40:04Z |
| format | Article |
| id | doaj.art-7f486159346745348e94ca55fe6c6366 |
| institution | Directory Open Access Journal |
| issn | 2476-8642 2536-6149 |
| language | English |
| last_indexed | 2024-04-10T17:40:04Z |
| publishDate | 2022-12-01 |
| publisher | Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu |
| record_format | Article |
| series | Annals of Health Research |
| spelling | doaj.art-7f486159346745348e94ca55fe6c63662023-02-03T15:08:07ZengMedical and Dental Consultants Association of Nigeria, OOUTH SagamuAnnals of Health Research2476-86422536-61492022-12-0184323328doi.org/10.30442/ahr.0804-09-184Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case ReportLawal YKaoje YSBansi IKThis is the case report of a 39-year-old lady who presented with clinical and laboratory features of secondary hypothyroidism two years after achieving clinical and biochemical resolution of Graves' disease and cessation of anti-thyroid medications. The thyroid function tests at presentation revealed: Serum T3 1.33ng/ml (normal range 0.8-1.7ng/ml), Serum T4 2.92 (normal range 4.5-12.0µg/dl), and TSH 0.2mIU/l (normal range 0.5-5.0mIU/l). Thyroid-related autoantibodies could not be assayed in the patient due to financial constraints. However, pointers to the possible autoimmune nature of secondary hypothyroidism include the recurrence of exophthalmos, dating of symptoms back to puerperium, relative lymphocytosis, and moderately elevated erythrocyte sedimentation rate (ESR). The patient was subsequently placed on levothyroxine and low-dose steroids, and the patient achieved clinical and biochemical euthyroidism in the sixth, ninth, and twelfth months of follow-up. This report is to demonstrate the development of secondary hypothyroidism following Graves' disease, and it also serves to highlight the judicious use of clinical acumen in the face of limited laboratory support to diagnose and treat endocrine disorders in resource-poor settings.https://www.annalsofhealthresearch.com/index.php/ahr/article/view/444autoimmune diseasegrave's diseaseprimary hyperthyroidismsecondnary hypothyroidismthyroid disease |
| spellingShingle | Lawal Y Kaoje YS Bansi IK Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report Annals of Health Research autoimmune disease grave's disease primary hyperthyroidism secondnary hypothyroidism thyroid disease |
| title | Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report |
| title_full | Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report |
| title_fullStr | Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report |
| title_full_unstemmed | Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report |
| title_short | Secondary hypothyroidism following the Resolution of Graves’ Disease: A Case Report |
| title_sort | secondary hypothyroidism following the resolution of graves disease a case report |
| topic | autoimmune disease grave's disease primary hyperthyroidism secondnary hypothyroidism thyroid disease |
| url | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/444 |
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