Metronidazole release using natural rubber latex as matrix
Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tiss...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2010-03-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392010000100013 |
| _version_ | 1811203276036636672 |
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| author | Rondinelli Donizetti Herculano Sérgio Augusto Catanzaro Guimarães Gustavo Campos Belmonte Marco Antonio Hungaro Duarte Osvaldo Novais de Oliveira Júnior Angela Kinoshita Carlos Frederico de Oliveira Graeff |
| author_facet | Rondinelli Donizetti Herculano Sérgio Augusto Catanzaro Guimarães Gustavo Campos Belmonte Marco Antonio Hungaro Duarte Osvaldo Novais de Oliveira Júnior Angela Kinoshita Carlos Frederico de Oliveira Graeff |
| author_sort | Rondinelli Donizetti Herculano |
| collection | DOAJ |
| description | Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours. |
| first_indexed | 2024-04-12T02:52:52Z |
| format | Article |
| id | doaj.art-7f4a5128433c44e68e6c837022d1b5ae |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-04-12T02:52:52Z |
| publishDate | 2010-03-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-7f4a5128433c44e68e6c837022d1b5ae2022-12-22T03:50:56ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392010-03-01131576110.1590/S1516-14392010000100013Metronidazole release using natural rubber latex as matrixRondinelli Donizetti HerculanoSérgio Augusto Catanzaro GuimarãesGustavo Campos BelmonteMarco Antonio Hungaro DuarteOsvaldo Novais de Oliveira JúniorAngela KinoshitaCarlos Frederico de Oliveira GraeffNatural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392010000100013biomaterialslatex membranemetronidazoledrug delivery system |
| spellingShingle | Rondinelli Donizetti Herculano Sérgio Augusto Catanzaro Guimarães Gustavo Campos Belmonte Marco Antonio Hungaro Duarte Osvaldo Novais de Oliveira Júnior Angela Kinoshita Carlos Frederico de Oliveira Graeff Metronidazole release using natural rubber latex as matrix Materials Research biomaterials latex membrane metronidazole drug delivery system |
| title | Metronidazole release using natural rubber latex as matrix |
| title_full | Metronidazole release using natural rubber latex as matrix |
| title_fullStr | Metronidazole release using natural rubber latex as matrix |
| title_full_unstemmed | Metronidazole release using natural rubber latex as matrix |
| title_short | Metronidazole release using natural rubber latex as matrix |
| title_sort | metronidazole release using natural rubber latex as matrix |
| topic | biomaterials latex membrane metronidazole drug delivery system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392010000100013 |
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